Background: Chronic arsenic exposure is a worldwide health problem. How arsenic exposure
promotes a variety of diseases is poorly understood, and specific relationships between …

The nucleotide 5-methylcytosine is involved in processes crucial in mammalian development,
such as X-chromosome inactivation and gene imprinting 1, 2, 3, 4, 5. In addition, cytosine …

In contrast to its clearly defined role as a multidrug efflux pump in neoplastic cells, the physiologic
function of P-glycoprotein (P-gly) in normal cells is unclear. Recent reports identifying P…

Background The microRNA-200 family participates in the maintenance of an epithelial
phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). …

Functional inactivation of BRCA1 is an important mechanism involved in breast cancer
pathogenesis. Mutation is often responsible for BRCA1 inactivation in familial breast cancer, but …

O 6 -Methylguanine DNA methyltransferase (MGMT) repairs the mutagenic and cytotoxic O
6 -alkylguanine lesions produced by environmental carcinogens and the chemotherapeutic …

The epigenetic silencing of tumor suppressor genes is a common event during carcinogenesis,
and often involves aberrant DNA methylation and histone modification of gene regulatory …

Expression of the O6-methylguanine DNA methyltransferase (MGMT) gene in human
glioma cell lines is strongly associated with resistance to the chemotherapeutic agent 1,3-bis(2-…

BRCA1 mRNA is reduced in sporadic breast cancer cells despite the lack of mutations.
Because a CpG island is found at the 5′ end of the BRCA1 gene, we hypothesized that the …

Abstract Changes in DNA methylation patterns are a common characteristic of cancer cells.
Recent studies suggest that DNA methylation affects not only discrete genes, but it can also …