Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches: a workshop report

JW van der Laan, RE Chapin, B Haenen… - Regulatory Toxicology …, 2012 - Elsevier
Reproductive toxicity testing is characterized by high animal use. For registration of
pharmaceutical compounds, developmental toxicity studies are usually conducted in both rat and …

Feasibility of single-shot H5N1 influenza vaccine in ferrets, macaques and rabbits

JGM Heldens, HL Glansbeek, LAT Hilgers, B Haenen… - Vaccine, 2010 - Elsevier
The feasibility of a single-shot, low-dose vaccination against pandemic influenza was
investigated. The immunogenicity and safety of whole inactivated, cell culture-derived H5N1 virus …

Effect of Hemodialysis on Peripheral Blood Monocyte Tumor Necrosis Factor-α, lnterleukin-6, and lnterleukin-8 Secretion in vitro

I Engelberts, GJM Francot, KML Leunissen, B Haenen… - Nephron, 1994 - karger.com
The influence of blood-membrane interaction on human peripheral blood monocyte tumor
necrosis factor-α (TNF), interleukin-6 (IL-6), and interleukin-8 (IL-8) secretion was measured …

Utility of rat liver slices to estimate hepatic clearance for application in physiologically based pharmacokinetic modeling: a study with tolbutamide, a compound with …

B Haenen, C Rompelberg, K van Twillert… - Drug metabolism and …, 2002 - ASPET
Liver slice experiments were performed to determine the slice intrinsic clearance and to
extrapolate this to the in vivo liver intrinsic clearance in a physiologically based pharmacokinetic …

[HTML][HTML] A planar conformation and the hydroxyl groups in the B and C rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives

…, GJ Hagemen, PJ Borm, A Bast, GRMM Haenen - Molecules, 2011 - mdpi.com
The polyphenol quercetin (Q) that has a high antioxidant capacity is a lead compound in the
design of antioxidants. We investigated the possibility of modifying quercetin while retaining …

Direct visualization of boron dopant distribution and coordination in individual chemical vapor deposition nanocrystalline B-doped diamond grains

…, SD Janssens, P Wagner, K Haenen… - Applied Physics …, 2012 - pubs.aip.org
… grain boundary dependence of the B uptake in CVD diamond … B was present in the amorphous
grain boundaries in CVD B:… in B:NCD diamond films from CVD, an indication that B could …

Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups

CGM Heijnen, G Haenen, FAA Van Acker… - Toxicology in vitro, 2001 - Elsevier
… , namely the catechol group in ring B and the hydroxyl (OH) group at … Of the flavonols tested
without a catechol group in ring B, … The catechol in ring B remains important. Also the 3-OH …

[HTML][HTML] The chemical reactivity of (-)-epicatechin quinone mainly resides in its B-ring

…, C Douny, GJM den Hartog, GRMM Haenen - Free radical biology and …, 2018 - Elsevier
… The gradient elution started with 10% B, increased linearly to 35% B over 4 min, and
continued to increase to 75% solvent B over 4.75 min before decreasing to 10% B over 5.50 min. …

Local boron environment in B-doped nanocrystalline diamond films

…, F Da Pieve, D Lamoen, J Verbeeck, K Haenen… - Nanoscale, 2012 - pubs.rsc.org
… In this work, conducting films of B-… the B concentration, distribution and the local B environment
in this type of thin nanocrystalline diamond films will be determined. The coordination of B

Deterministic all-optical switching of synthetic ferrimagnets using single femtosecond laser pulses

…, MJG Peeters, SRR Haenen, R Lavrijsen, B Koopmans - Physical review B, 2017 - APS
We experimentally demonstrate single-pulse all-optical switching in Pt/Co/Gd stacks using
linearly polarized laser pulses. This shows that thermal single-pulse switching is not limited to …