Background— DNA variants appearing to predispose to drug-associated “acquired” long-QT
syndrome (aLQTS) have been reported in congenital long-QT disease genes. However, the …

Background—Several cases of QT prolongation and ventricular tachyarrhythmia have been
reported with domperidone, a gastrokinetic and antiemetic agent available worldwide but …

Maintenance of normal cardiac rhythm requires coordinated activity of ion channels and
transporters that allow well-ordered propagation of electrical impulses across the myocardium. …

Background—Lengthening of the QT interval and torsades de pointes resulting in cardiac
arrests and deaths have been noticed during treatment with cisapride, a newly developed …

Classic antihistamines, namely diphenhydramine, chlorpheniramine, clemastine,
perphenazine, hydroxyzine, and tripelennamine, share structural features with substrates and …

Background— Cases of QT prolongation, torsades de pointes, and sudden death have been
reported with arsenic trioxide (As 2 O 3 ), a highly effective agent for acute promyelocytic …

Proarrhythmia has been observed with the antipsychotic agent thioridazine (THIO). The
mechanisms underlying these effects are unknown. The objectives of this study were 1) to …

Droperidol Blocks Cardiac I Kr . Introduction: Torsades de pointes have been observed during
treatment with droperidol, a butyrophenone neuroleptic agent. Our objectives were (1) to …

QRS widening and QT prolongation are associated with bupropion. The objectives were to
elucidate its cardiac electrophysiological properties. Patch‐clamp technique was used to …

Background—Several cases of unexpected death have been reported with sildenafil in
patients predisposed to ischemic cardiac events. Although acute episodes of ischemia could …