Human renal membrane transporters play key roles in the disposition of renally cleared
drugs and endogenous substrates, but their ontogeny is largely unknown. Using 184 human …

Developmental changes in the biological processes involved in the disposition of drugs,
such as membrane transporter expression and activity, may alter the drug exposure and …

The intestinal influx oligopeptide transporter peptide transporter 1 (PEPT1) (SLC15A1) is
best known for nutrient-derived di- and tripeptide transport. Its role in drug absorption is …

… Author links open overlay panel Bianca D. van Groen a , Evita van de Steeg b , Miriam G.
Mooij c , Marola MH van Lipzig b , Barbara AE de Koning d , Robert M. Verdijk e , Heleen M. …

Human hepatic membrane-embedded transporter proteins are involved in trafficking endogenous
and exogenous substrates. Even though impact of transporters on pharmacokinetics is …

Midazolam is metabolized by the developmentally regulated intestinal and hepatic drug‐metabolizing
enzyme cytochrome P450 (CYP) 3A4/5. It is frequently administered orally to …

Aims Drug disposition in children may vary from adults due to age‐related variation in drug
metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in …

The disposition of a drug is driven by various processes, such as drug metabolism, drug
transport, glomerular filtration and body composition. These processes are subject to …

Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics,
but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed …

On April 24, 2019, a symposium on Pediatric Pharmacokinetics and Dose Predictions was
held as a satellite meeting to the 10th Juvenile Toxicity Symposium. This symposium brought …