Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active …
…, SK Roy, TR Tephly, BL Coffman… - The Journal of …, 1998 - Am Soc Clin Investig
Irinotecan (CPT-11) is a promising antitumor agent, recently approved for use in patients
with metastatic colorectal cancer. Its active metabolite, SN-38, is glucuronidated by hepatic …
with metastatic colorectal cancer. Its active metabolite, SN-38, is glucuronidated by hepatic …
Human UGT2B7 catalyzes morphine glucuronidation
BL Coffman, GR Rios, CD King, TR Tephly - Drug Metabolism and …, 1997 - ASPET
A human UDP-glucuronosyltransferase (UGT) catalyzing the glucuronidation of morphine
has been identified. A full length cDNA was isolated from a human liver cDNA library and …
has been identified. A full length cDNA was isolated from a human liver cDNA library and …
The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y (268) and UGT2B7H (268)
BL Coffman, CD King, GR Rios, TR Tephly - Drug Metabolism and …, 1998 - ASPET
UGT2B7 has been cloned and expressed previously in COS cells and HK293 cells. Two
forms have been identified: one with a tyrosine and one with a histidine at position 268. …
forms have been identified: one with a tyrosine and one with a histidine at position 268. …
Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7
…, B Mojarrabi, TR Tephly, MD Green, BL Coffman… - The Journal of steroid …, 1999 - Elsevier
In this work, UDP-glucuronosyltransferases (UGTs), UGT1A3, 2B7(H268) and 2B7(Y268),
stably expressed in human embryonic kidney cells (HK293) were used to assess …
stably expressed in human embryonic kidney cells (HK293) were used to assess …
The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1
CD King, MD Green, GR Rios, BL Coffman… - Archives of biochemistry …, 1996 - Elsevier
Rat and human UDP-glucuronosyltransferase (UGT)1.1 share >70% identity in their
deduced primary amino acid sequences. We have previously shown that rat UGT1.1, stably …
deduced primary amino acid sequences. We have previously shown that rat UGT1.1, stably …
Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7
Z Cheng, GR Rios, CD King, BL Coffman… - Toxicological …, 1998 - Elsevier
Catechol estrogens are major estrogen metabolites in mammals and are the most potent
naturally occurring inhibitors of catecholamine metabolism. These estrogen compounds have …
naturally occurring inhibitors of catecholamine metabolism. These estrogen compounds have …
Opioids bind to the amino acids 84 to 118 of UDP-glucuronosyltransferase UGT2B7
BL Coffman, WR Kearney, S Goldsmith, BM Knosp… - Molecular …, 2003 - ASPET
The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes
the conjugation of many endogenous and exogenous compounds, among them opioids, …
the conjugation of many endogenous and exogenous compounds, among them opioids, …
Analysis of opioid binding to UDP-glucuronosyltransferase 2B7 fusion proteins using nuclear magnetic resonance spectroscopy
BL Coffman, WR Kearney, MD Green, RG Lowery… - Molecular …, 2001 - ASPET
The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes
the conjugation of many endogenous and exogenous compounds, among them opioids, …
the conjugation of many endogenous and exogenous compounds, among them opioids, …
Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase
BL Coffman, TR Tephly, YM Irshaid, MD Green… - Archives of biochemistry …, 1990 - Elsevier
A human liver microsomal UDPglucuronosyltransferase (UDPGT) that demonstrates reactivity
with estriol (pI 7.4 UDPGT) has been purified to homogeneity and characterized further. …
with estriol (pI 7.4 UDPGT) has been purified to homogeneity and characterized further. …
Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of …
BL Coffman, MD Green, CD King, TR Tephly - Molecular pharmacology, 1995 - ASPET
A chicken anti-rat polyclonal antibody to a purified rat liver UDP-glucuronosyltransferase (UGT)
with catalytic activity toward opioid substrates was used to screen a liver cDNA library …
with catalytic activity toward opioid substrates was used to screen a liver cDNA library …