The selective serotonin reuptake inhibitors (SSRIs) comprise citalopram, fluoxetine,
fluvoxamine, paroxetine, and sertraline and they differ from each other in chemical structure, by …

The aim of this study was to evaluate the (3S)-3-hydroxylation and the N-oxidation of
quinidine as biomarkers for cytochrome P-450 (CYP)3A4 activity in human liver microsome …

Clozapine is an atypical antipsychotic drug that is mainly used for the treatment of refractory
schizophrenia. Clozapine is eliminated by oxidation in the liver, predominantly by …

Caffeine metabolism via the 3-demethylation pathway is sequentially catalyzed by cytochrome
P4501A2 (CYP1A2), xanthine oxidase, and N-acetyltransferase. The activities of the three …

Research question To evaluate the immunogenicity of follitropin delta in repeated ovarian
stimulation. Design Controlled, assessor-blind trial in IVF/intracytoplasmic sperm injection …

The selective serotonin re‐uptake inhibitor, fluvoxamine, is a very potent inhibitor of CYP1A2,
and accordingly causes pharmacokinetic interactions with drugs metabolised by CYP1A2, …

Objective To investigate the interaction between fluvoxamine and chloroguanide (INN,
proguanil) to confirm that fluvoxamine inhibits CYP2C19. Methods The study was carried out with …

Theophylline is predominantly metabolized by cytochrome P4501A2 (CYP1A2). A possible
interaction between griseofulvin and theophylline was reported to our laboratory, which led …

Objective Our objective was to study the effect of recombinant human growth hormone (rhGH)
on hepatic cytochrome P450 (CYP) activity in 30 healthy elderly men. Methods The study …

Objectives To further substantiate the role of CYP1A2 and CYP3A4 for the N‐demethylation
in vivo. At least three different P450s appear to be responsible for the N‐demethylation of …