Expanding the Genetic Code of Escherichia coli

L Wang, A Brock, B Herberich, PG Schultz - Science, 2001 - science.org
A unique transfer RNA (tRNA)/aminoacyl-tRNA synthetase pair has been generated that
expands the number of genetically encoded amino acids in Escherichia coli. When introduced …

An efficient system for the evolution of aminoacyl-tRNA synthetase specificity

SW Santoro, L Wang, B Herberich, DS King… - Nature …, 2002 - nature.com
A variety of strategies to incorporate unnatural amino acids into proteins have been pursued
1 , 2 , 3 , 4 , 5 , but all have limitations with respect to technical accessibility, scalability, …

Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold

B Herberich, GQ Cao, PP Chakrabarti… - Journal of medicinal …, 2008 - ACS Publications
Investigations into the structure−activity relationships (SAR) of a series of phthalazine-based
inhibitors of p38 are described. These efforts originated from quinazoline 1 and through …

Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases

…, YY Bo, SK Booker, VJ Cee, B Herberich… - Journal of medicinal …, 2012 - ACS Publications
A highly selective series of inhibitors of the class I phosphatidylinositol 3-kinases (PI3Ks) has
been designed and synthesized. Starting from the dual PI3K/mTOR inhibitor 5, a structure-…

Discovery of (R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-one, a …

…, H Eastwood, N Guerrero, B Herberich… - Journal of Medicinal …, 2019 - ACS Publications
Pim kinases are a family of constitutively active serine/threonine kinases that are partially
redundant and regulate multiple pathways important for cell growth and survival. In human …

Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx-1 Peptide–Antibody Conjugates

…, L Yin, H Liu, J Gingras, BE Hall, B Herberich… - ACS chemical …, 2017 - ACS Publications
The voltage-gated sodium channel Na V 1.7 is a genetically validated pain target under
investigation for the development of analgesics. A therapeutic with a less frequent dosing …

Discovery and optimization of quinazolinone-pyrrolopyrrolones as potent and orally bioavailable pan-pim kinase inhibitors

…, H Eastwood, N Guerrero, B Herberich… - Journal of Medicinal …, 2016 - ACS Publications
The high expression of proviral insertion site of Moloney murine leukemia virus kinases (Pim-1,
-2, and -3) in cancers, particularly the hematopoietic malignancies, is believed to play a …

Engineering NaV1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics

…, TE Nixey, JR Falsey, B Herberich… - ACS Chemical …, 2019 - ACS Publications
Drug discovery research on new pain targets with human genetic validation, including the
voltage-gated sodium channel Na V 1.7, is being pursued to address the unmet medical need …

Discovery and evaluation of 7-alkyl-1, 5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38α mitogen-activated protein …

LH Pettus, RP Wurz, S Xu, B Herberich… - Journal of medicinal …, 2010 - ACS Publications
The p38α mitogen-activated protein (MAP) kinase is a central signaling molecule in many
proinflammatory pathways, regulating the cellular response to a multitude of external stimuli …

Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors

RP Wurz, C Sastri, DC D'Amico, B Herberich… - Bioorganic & medicinal …, 2016 - Elsevier
High levels of Pim expression have been implicated in several hematopoietic and solid tumor
cancers, suggesting that inhibition of Pim signaling could provide patients with therapeutic …