Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human micro-somal protein and …

…, RJ Edwards, J Brian Houston, BG Lake… - Current drug …, 2007 - ingentaconnect.com
Reported predictions of human in vivo hepatic clearance from in vitro data have used a variety
of values for the scaling factors human microsomal protein (MPPGL) and hepatocellularity …

A cancer risk assessment of di (2-ethylhexyl) phthalate: application of the new US EPA Risk Assessment Guidelines

…, BG Lake, J Swenberg, C Wilkinson, G Williams… - Regulatory Toxicology …, 1999 - Elsevier
The current United States Environmental Protection Agency (EPA) classification of di(2-ethylhexyl)phthalate
(DEHP) as a B2 “probable human” carcinogen is based on outdated …

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor …

…, R Schoeny, W Xie, BG Lake - Critical reviews in …, 2014 - Taylor & Francis
The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are important
nuclear receptors involved in the regulation of cellular responses from exposure to many …

Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

…, PJ Young, RJ Price, AP Tonelli, BG Lake - Drug Metabolism and …, 2001 - ASPET
The metabolism of cis-tramadol has been studied in human liver microsomes and in cDNA-expressed
human cytochrome P-450 (CYP) isoforms. Human liver microsomes catalyzed the …

Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?

…, C Elcombe, P Fenner-Crisp, BG Lake… - Regulatory Toxicology …, 1998 - Elsevier
The purpose of the workshop “Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic
Hazard to Humans?” was to provide a review of the current state of the science on …

Induction of drug metabolism: species differences and toxicological relevance

MJ Graham, BG Lake - Toxicology, 2008 - Elsevier
A large number of drugs and other chemicals have been shown to induce hepatic microsomal
cytochrome P450 (CYP) forms in experimental animals and humans. Most CYP forms are …

Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling

…, C Stella, A Campbell, BG Lake… - Journal of proteome …, 2011 - ACS Publications
Consumption of cruciferous vegetables (CVs) is inversely correlated to many human
diseases including cancer (breast, lung, and bladder), diabetes, and cardiovascular and …

Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine (PhIP) in humans

…, AR Boobis, NJ Gooderham, BG Lake - …, 2004 - academic.oup.com
Consumption of red meat is associated with an increased risk of colorectal cancer, whereas
cruciferous vegetable consumption reduces cancer risk. While the mechanisms remain to be …

Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals

BG Lake - Annual Review of Pharmacology and Toxicology, 1995 - annualreviews.org
A wide variety of chemicals have been shown to produce liver enlargement, peroxisome
proliferation, and induction of peroxisomal and microsomal fatty acid-oxidizing enzyme activities …

Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices

…, JM Tredger, O Pelkonen, AR Boobis, BG Lake - Drug Metabolism and …, 2000 - ASPET
The maintenance of the major hepatic cytochrome P450 (CYP) enzymes has been studied
in precision-cut human liver slices cultured for up to 72 h in supplemented RPMI 1640 …