Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols
JL Durant, WF Busby Jr, AL Lafleur, BW Penman… - Mutation Research …, 1996 - Elsevier
Polycyclic aromatic compounds (PAC) are ubiquitous pollutants in urban air that may pose
risks to human health. In order to better assess the health risks associated with this class of …
risks to human health. In order to better assess the health risks associated with this class of …
Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation
EL Code, CL Crespi, BW Penman, FJ Gonzalez… - Drug Metabolism and …, 1997 - ASPET
The level of expression and interindividual variation in human hepatic microsomal cytochrome
P450 (CYP) 2B6 was characterized using a polyclonal antibody (WB-2B6) raised against …
P450 (CYP) 2B6 was characterized using a polyclonal antibody (WB-2B6) raised against …
A tobacco smoke-derived nitrosamine, 4-(methytnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytocbrome P450s including the polymorphic …
CL Crespi, BW Penman, HV Gelboin… - …, 1991 - academic.oup.com
We have developed a human B-lymphoblastoid cell line, designated 2D6/Hol, which stably
expresses human cyto chrome P450 CYP2D6 cDNA. This cell line exhibits bufuralol 11-…
expresses human cyto chrome P450 CYP2D6 cDNA. This cell line exhibits bufuralol 11-…
Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay
TR Skopek, HL Liber, BW Penman, WG Thilly - … and biophysical research …, 1978 - Elsevier
A thymidine kinase heterozygote designated H2BT has been isolated from the human
lymphoblast line HH4. Significant increase in the trifluorothymidine-resistant fraction was …
lymphoblast line HH4. Significant increase in the trifluorothymidine-resistant fraction was …
Mutagenicity of C24H14 PAH in human cells expressing CYP1A1
…, WF Busby Jr, LL Donhoffner, BW Penman… - … /Genetic Toxicology and …, 1999 - Elsevier
Relatively little is known about the mutagenicity of C 24 H 14 PAH, a diverse group of five-
and six-ring PAH, some of which are present at trace levels in the environment. To better …
and six-ring PAH, some of which are present at trace levels in the environment. To better …
Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates
EE Furth, WG Thilly, BW Penman, HL Liber… - Analytical …, 1981 - Elsevier
We describe a microtiter plating technique which eliminates the need for soft agar and fibroblast
feeder layers to determine the colony-forming ability of diploid human lymphoblast lines. …
feeder layers to determine the colony-forming ability of diploid human lymphoblast lines. …
Bioassay-directed chemical analysis of Los Angeles airborne particulate matter using a human cell mutagenicity assay
MP Hannigan, GR Cass, BW Penman… - Environmental …, 1998 - ACS Publications
The human cell mutagenicity of Los Angeles airborne fine particulate matter is examined via
bioassay-directed chemical analysis. A 1993 composite fine particle sample is separated …
bioassay-directed chemical analysis. A 1993 composite fine particle sample is separated …
Development of a human lymphoblastoid cell line constitutively expressing human CYP1B1 cDNA: substrate specificity with model substrates and promutagens
CL Crespi, B W-Penman, DT Steimel, T Smith… - …, 1997 - academic.oup.com
An AHH-1 TK +/− cell derivative was developed that stably expresses human cytochrome
P4501B1 (CYP1B1) cDNA in an extrachromosomal vector which confers resistance to 1-…
P4501B1 (CYP1B1) cDNA in an extrachromosomal vector which confers resistance to 1-…
The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3
CL Crespi, BW Penman, DT Steimel… - …, 1991 - academic.oup.com
We have developed a human lymphoblastoid cell line, designated 3A4/HoI, which stably
expresses human CYP3A4 cDNA. This cell line exhibited testosterone 6β-hydroxylase activity, …
expresses human CYP3A4 cDNA. This cell line exhibited testosterone 6β-hydroxylase activity, …
Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions
CL Crespi, BW Penman - Advances in pharmacology, 1997 - Elsevier
Publisher Summary cDNA-expressed enzymes can be used to study the cytochrome P450
form-selective inhibition by drugs or drug candidates. This analysis is accomplished through …
form-selective inhibition by drugs or drug candidates. This analysis is accomplished through …