Conformational analysis has resulted in the design and synthesis of somatostatin analogues
which show increased duration of action 1–3 . The introduction of covalent conformational …

Simvastatin (SV) is a lactone prodrug used for the treatment of hypercholesterolemia. Upon
incubation of SV with liver microsomal preparations from human donors, four major …

Results Production of 4-Fluorothreonine in Complex Media Since the antimetabolite activity
of 4-fluorothreonine was first detected in a medium containing soy bean casein, it was …

Our isolated Qi0 (yellow) melted at 49.5-50.5. Found: C, 81.98, 82.05; IH, 10.38, 10.31. Hy-drogenation
of Qio resulted in an absorption of about 11 moles of hydrogen. Oxidation of the …

Thestructure and stereochemistry of the potent new 0-lactam antibiotic thienamycin were
determined as shown in formula 22. Thienamycin (1) was discovered in fermentation broths of …

A series of nonpeptide somatostatin agonists which bind selectively and with high affinity to
somatostatin receptor subtype 2 (sst2) have been synthesized. One of these compounds, L-…

Caspofungin acetate (MK-0991) is a semisynthetic pneumocandin derivative being developed
as a parenteral antifungal agent with broad-spectrum activity against systemic infections …

FK506 and FK520 are 23-membered macrocyclic polyketides with potent immunosuppressive
and antifungal activities. The gene encoding 31-O-demethyl-FK506 methyltransferase, …

Photodegradation of avermectin Bi „thinfilms under artificial light (above 260 nm) for short
periods of time (greater than 60% of parentcompound remaining) resulted in the formation of at …

The mechanism of 1, 3-dipolar cycloadditions has been a topic of lively debate.* 12™ 4 For
nitrile oxide cycloadditions, experimental data havebeen interpreted either as supportive of a …