A particulate preparation was obtained by low speed centrifugation of guinea pig cerebral
cortical homogenates prepared with a Krebs- Henseleit buffer. Light microscopic examination, …

… CREVELING HERBERT WEISSBACH SIDNEY UDENFRIEND Section of Experimental
Therapeutics and Laboratory of Clinical Biochemistry, National Heart Institute., Bethesda, …

A simple and sensitive method for measuring the effect of neurohormones and other
chemical agents on the formation of adenosine 3′,5′‐cyclic monophosphate (cyclic 3′,5′‐AMP…

N-Carbobenzyloxy-3, 4-dihydroxyplienethylamine-/3,/3-H3 suffers no loss of tritium activity
when subjected to oxidation to the quinone, to 1, 4-addition reactions involving catalysis by …

The methylation of substituted catechols catalyzed by catechol O-methyltransferase (EC 2.1.1.6
) with S-adenosylmethionine as methyl donor results in the formation of a mixture of m- …

In vitro, O-methylation of physiological substrates of catechol O-methyltransferase (EC 2.1.1.6
) such as (nor)epinephrine, dopamine, 3,4-dihydroxyphenylacetic acid, 3,4-…

ROTMAN, A., DALY, JW & CREVELING, CR (1976) Oxygen-dependent reaction of 6-hydroxydopamine,
5, 6-dihydroxytryptamine, and related compounds with proteins in vitro: a model …

The enzyme dopamine-β-oxidase not only effects the hydroxylation of dopamine to
norepinephrine, but accepts as substrates a wide vareety of phenethylamine derivatives such as …

NIKODEJEVIC, B., S. SENOR, JW DALY AND CR CREVELING: Catechol-O-methyl-transferase.
II. A new class of inhibitors of catechol-O-methyltransferase; 3, 5-dihydroxy-4-…

Previous studies by others have shown that norepinephrine is metabolized largely by two
alternate enzymes: catechol-O-methyl transferase and monoamine oxidase. The present study …