Development of effective pharmaceutical interventions in acquired immunodeficiency syndrome
(AIDS) is a high priority goal. About 10 million individuals worldwide are estimated to be …

A series of nonnucleoside 3-aminopyridin-2 (lH)-one derivatives was synthesized and
evaluated for HIV-1 RT inhibitory properties. Several analogs proved to be potent and highly …

A new series of potent specific 2-pyridinone reverse transcriptase (RT) inhibitors was
developed based on the preliminary development lead 3-[(phthalimido) ethyl]-5-ethyl-6-…

The development of potent and effective antiviral drugs for the control of human
immunodeficiency virus type 1 (HIV-1) infection is one of the more pressing goals of contemporary …

In an ongoing effort to develop novel nonnucleoside, specific human immunodeficiencyvirus
type 1 (HIV-1) reverse transcriptase (RT) inhibitors, a series of 3-[(pyridylmethyl) amino]-and …

A series of 6, ll-dihydro-5R-pyrrolo [2, lb][3] benzazepin-ll-ones, 4, has been prepared as
intermediates for potential CNSdrugs. Substituentsin the pyrrole ring of 4 were introduced by …

An extensive series of novel 4-substituted 3-hydroxy-Lff-pyrrole-2, 5-dione derivatives has
been prepared and studied as inhibitors of glycolicacid oxidase (GAO). Compounds …

A series of compounds containing the 3-hydroxy-4R-pyran-4-one nucleus has
beensynthesized and tested as potential skeletal muscle relaxante. Reduction of 2-(azidomethyl)-5-…

Materials and Methods Fermentation of A. terreus1^ Tubes of lyophilized culture MF-4845were
suspended each in 10 ml of sterilized mediumconsisting of the following nutrients: Corn …

Fourteen new 4-substituted 2, 4-dioxobutanoic acids have been synthesized. These compounds,
all of which contain lipophilic 4-substituents, are potent inhibitors in vitro of porcine liver …