Metallothionein: an intracellular protein to protect against cadmium toxicity

CD Klaassen, J Liu, S Choudhuri - Annual review of …, 1999 - annualreviews.org
… its function in protecting against Cd toxicity. Repeated administration of Cd to MT-null mice
… Human studies indicate that 7% of the general population have renal dysfunction from Cd

Metallothionein protection of cadmium toxicity

CD Klaassen, J Liu, BA Diwan - Toxicology and applied pharmacology, 2009 - Elsevier
… the gastrointestinal absorption of Cd, but MT plays important roles in Cd retention in tissues
and dramatically decreases biliary excretion of Cd. Cd-bound to MT is responsible for Cd

Xenobiotic, bile acid, and cholesterol transporters: function and regulation

CD Klaassen, LM Aleksunes - Pharmacological reviews, 2010 - ASPET
Transporters influence the disposition of chemicals within the body by participating in absorption,
distribution, and elimination. Transporters of the solute carrier family (SLC) comprise a …

[BOOK][B] Casarett and Doull's toxicology: the basic science of poisons

CD Klaassen, MO Amdur - 2013 - researchgate.net
The question of what constitutes an acceptable risk is a matter of judgement. Such decisions
are multifaceted and complex, and involve a balance of risk and benefit. High risks may be …

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

…, A LaTour, Y Liu, CD Klaassen… - Proceedings of the …, 2001 - National Acad Sciences
The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone
16α-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and …

[PDF][PDF] Heavy metals and heavy-metal antagonists

CD Klaassen - … and Gilman's The Pharmacological Basis of …, 2006 - ndl.ethernet.edu.et
… Cantilena, LR, Jr., and Klaassen, CD Decreased effectiveness of chelation therapy with time
after … Cantilena, LR, Jr., and Klaassen, CD The effect of chelating agents on the excretion of …

[PDF][PDF] Principles of toxicology

DL Eaton, CD Klaassen - Casarett and Doull's Toxicology …, 2001 - courseware.cutm.ac.in
■ Descriptive animal toxicity testing assumes that the e ects produced by a compound in
laboratory animals, when properly quali ed, are applicable to humans, and that exposure o …

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux …

S Choudhuri, CD Klaassen - International journal of …, 2006 - journals.sagepub.com
The ATP-binding cassette (ABC) transporters constitute a large family of membrane proteins,
which transport a variety of compounds through the membrane against a concentration …

Mechanisms of bile formation, hepatic uptake, and biliary excretion

CD Klaassen, JB Watkins - Pharmacol Rev, 1984 - hero.epa.gov
Biliary excretion of xenobiotics is a complex process involving uptake into liver cells,
intracellular sequestration and/or biotransformation, and transport into bile. A description of liver …

The importance of 3 '‐phosphoadenosine 5 '‐phosphosulfate (PAPS) in the regulation of sulfation

CD Klaassen, JW Boles - The FASEB Journal, 1997 - Wiley Online Library
Sulfation is the transfer of a sulfate group from 3'‐phosphoadenosine 5'‐phosphosulfate (PAPS)
to a substrate that is catalyzed by a family of sulfotransferase enzymes. Many different …