Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity
CI Ghanem, MJ Pérez, JE Manautou… - Pharmacological …, 2016 - Elsevier
… RNA isolation and quantification was performed as detailed in Ghanem et al. [127]. Data are
… Ghanem and Aldo D. Mottino respectively, and by a grant from National Institutes of Health (…
… Ghanem and Aldo D. Mottino respectively, and by a grant from National Institutes of Health (…
[HTML][HTML] Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity
…, SSM Villanueva, MG Luquita, AD Mottino, CI Ghanem… - PloS one, 2015 - journals.plos.org
Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide. Sorafenib is
the only drug available that improves the overall survival of HCC patients. P-glycoprotein (P-gp)…
the only drug available that improves the overall survival of HCC patients. P-glycoprotein (P-gp)…
Role and Regulation of Hepatobiliary ATP-Binding Cassette Transporters during Chemical-Induced Liver Injury
CI Ghanem, JE Manautou - Drug Metabolism and Disposition, 2022 - ASPET
Severity of drug-induced liver injury (DILI) ranges from mild, asymptomatic, and transient
elevations in liver function tests to irreversible liver damage, often needing transplantation. …
elevations in liver function tests to irreversible liver damage, often needing transplantation. …
[HTML][HTML] Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: In Vitro, Ex Vivo, and In Silico Studies
…, E Sousa, C Rocha-Pereira, CI Ghanem… - Molecules, 2019 - mdpi.com
P-glycoprotein (P-gp) plays a crucial role in the protection of susceptible organs, by significantly
decreasing the absorption/distribution of harmful xenobiotics and, consequently, their …
decreasing the absorption/distribution of harmful xenobiotics and, consequently, their …
Modulation of hepatic MRP3/ABCC3 by xenobiotics and pathophysiological conditions: role in drug pharmacokinetics
CI Ghanem, JE Manautou - Current medicinal chemistry, 2019 - ingentaconnect.com
Liver transporters play an important role in the pharmacokinetics and disposition of
pharmaceuticals, environmental contaminants, and endogenous compounds. Among them, the …
pharmaceuticals, environmental contaminants, and endogenous compounds. Among them, the …
The effect of acetaminophen on the expression of BCRP in trophoblast cells impairs the placental barrier to bile acids during maternal cholestasis
…, E Gonzalez-Sanchez, MJ Perez, CI Ghanem… - Toxicology and applied …, 2014 - Elsevier
Acetaminophen is used as first-choice drug for pain relief during pregnancy. Here we have
investigated the effect of acetaminophen at subtoxic doses on the expression of ABC export …
investigated the effect of acetaminophen at subtoxic doses on the expression of ABC export …
Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein
CI Ghanem, PC Gómez, MC Arana, M Perassolo… - Biochemical …, 2004 - Elsevier
We evaluated the effect of acetaminophen (APAP), given as a single, 1g/kg body weight dose,
on expression and activity of rat liver multidrug resistance-associated protein 2 (Mrp2) and …
on expression and activity of rat liver multidrug resistance-associated protein 2 (Mrp2) and …
Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose
CI Ghanem, ML Ruiz, SSM Villanueva… - Biochemical …, 2009 - Elsevier
Development of resistance to toxic effects of acetaminophen (APAP) was reported in rodents
and humans, though the mechanism is only partially understood. We examined in rats the …
and humans, though the mechanism is only partially understood. We examined in rats the …
Role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the transcriptional regulation of brain ABC transporters during acute acetaminophen (APAP) intoxication in …
CI Ghanem, S Rudraiah, AM Bataille, MB Vigo… - Biochemical …, 2015 - Elsevier
Abstract Changes in expression of liver ABC transporters have been described during acute
APAP intoxication. However, the effect of APAP on brain ABC transporters is poorly …
APAP intoxication. However, the effect of APAP on brain ABC transporters is poorly …
The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug …
…, MT Ronco, AM Bataille, CI Ghanem… - Toxicology and applied …, 2016 - Elsevier
Oxidative stress is a frequent cause underlying drug-induced hepatotoxicity. Benznidazole (BZL)
is the only trypanocidal agent available for treatment of Chagas disease in endemic …
is the only trypanocidal agent available for treatment of Chagas disease in endemic …