User profiles for C. L. Woodard

Cameron L Woodard

Postdoctoral Fellow, UCSF
Verified email at ucsf.edu
Cited by 310

Oxindole-Based Compounds Are Selective Inhibitors of Plasmodium falciparum Cyclin Dependent Protein Kinases

CL Woodard, Z Li, AK Kathcart, J Terrell… - Journal of medicinal …, 2003 - ACS Publications
Cyclin dependent protein kinases (CDKs) have become attractive drug targets in an effort to
identify effective inhibitors of the parasite Plasmodium falciparum, the causative agent of the …

[HTML][HTML] Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models

MP Parsons, MP Vanni, CL Woodard, R Kang… - Nature …, 2016 - nature.com
It has become well accepted that Huntington disease (HD) is associated with impaired glutamate
uptake, resulting in a prolonged time-course of extracellular glutamate that contributes …

Design and synthesis of Pfmrk inhibitors as potential antimalarial agents

Z Xiao, NC Waters, CL Woodard, Z Li, PK Li - Bioorganic & medicinal …, 2001 - Elsevier
The synthesis and inhibitory activities of 10 potential inhibitors of Pfmrk, a Plasmodium
falciparum cyclin-dependent protein kinase, are described. The most potent inhibitor is a 3-phenyl…

[PDF][PDF] Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway

D Gallagher, AA Norman, CL Woodard, G Yang… - Cell stem cell, 2013 - cell.com
The mechanisms that regulate the establishment of adult stem cell pools during normal and
perturbed mammalian development are still largely unknown. Here, we asked whether a …

[PDF][PDF] The protein tyrosine phosphatase receptor delta regulates developmental neurogenesis

H Tomita, F Cornejo, B Aranda-Pino, CL Woodard… - Cell reports, 2020 - cell.com
PTPRD is a receptor protein tyrosine phosphatase that is genetically associated with
neurodevelopmental disorders. Here, we asked whether Ptprd mutations cause aberrant neural …

Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1, 3-diaryl-2-propenones

JA Geyer, SM Keenan, CL Woodard… - Bioorganic & medicinal …, 2009 - Elsevier
The cyclin dependent protein kinases, Pfmrk and PfPK5, most likely play an essential role in
cell cycle control and differentiation in Plasmodium falciparum and are thus an attractive …

Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum

…, P Sellers, JT Ferlan, PJ Lee, Z Li, CL Woodard… - Molecular and …, 2002 - Elsevier
The genome of the malaria parasite, Plasmodium falciparum, appears to contain the proteins
necessary for a Type II dissociated fatty acid biosynthetic system. Here we report the …

A Three-Dimensional in Silico Pharmacophore Model for Inhibition of Plasmodium falciparum Cyclin-Dependent Kinases and Discovery of Different Classes of Novel …

AK Bhattacharjee, JA Geyer, CL Woodard… - Journal of medicinal …, 2004 - ACS Publications
The cell division cycle is regulated by a family of cyclin-dependent protein kinases (CDKs)
that are functionally conserved among many eukaryotic species. The characterization of …

Direct assessment of presynaptic modulation of cortico-striatal glutamate release in a Huntington's disease mouse model

ET Koch, CL Woodard… - Journal of …, 2018 - journals.physiology.org
Glutamate is the main excitatory neurotransmitter in the brain, and impairments in its
signaling are associated with many neurological disorders, including Huntington’s disease (HD). …

An automated home-cage system to assess learning and performance of a skilled motor task in a mouse model of Huntington's disease

CL Woodard, F Bolaņos, JD Boyd, G Silasi, TH Murphy… - Eneuro, 2017 - eneuro.org
Behavioral testing is a critical step in assessing the validity of rodent models of neurodegenerative
disease, as well as evaluating the efficacy of pharmacological interventions. In …