The metabolism and excretion of buprenorphine in humans.

EJ Cone, CW Gorodetzky, D Yousefnejad… - Drug Metabolism and …, 1984 - ASPET
Buprenorphine, a powerful mixed agonist-antagonist analgesic which shows promise of
providing maintenance pharmacotherapy for heroin addicts, is metabolized in male human …

Isolation and identification of morphine 3-and 6-glucuronides, morphine 3, 6-diglucuronide, morphine 3-ethereal sulfate, normorphine, and normorphine 6 …

SY Yeh, CW Gorodetzky, HA Krebs - Journal of pharmaceutical sciences, 1977 - Elsevier
Morphine metabolites were isolated with column chromatography on a resin and neutral
aluminum oxide and TLC from the urine of morphine-dependent subjects maintained on …

Real‐world efficacy of prescription and over‐the‐counter nicotine replacement therapy

…, SJ Hellebusch, J Gorsline, CW Gorodetzky… - …, 2002 - Wiley Online Library
Aims To assess smoking cessation rates achieved with nicotine gum and patch in simulated
over‐the‐counter (OTC) and actual prescription (Rx) settings. Design Separate open‐label …

[HTML][HTML] A phase III, randomized, multi-center, double blind, placebo controlled study of safety and efficacy of lofexidine for relief of symptoms in individuals undergoing …

CW Gorodetzky, SL Walsh, PR Martin, AJ Saxon… - Drug and alcohol …, 2017 - Elsevier
Background Lofexidine is an alpha-2-adrenergic receptor agonist approved in the United
Kingdom (UK) for the treatment of opioid withdrawal symptoms. Lofexidine has demonstrated …

[PDF][PDF] Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog.

EJ Cone, WD Darwin, CW Gorodetzky… - Drug Metabolism and …, 1978 - researchgate.net
The metabolism of hydrocodone was studied in man, rat, guinea pig, rabbit, and dog.
Routes of metabolism included 0-demethylation, N-dealkylation, and 6-keto-reduction to the …

[HTML][HTML] Safety and efficacy of lofexidine for medically managed opioid withdrawal: a randomized controlled clinical trial

…, K Gullo, T Clinch, CW Gorodetzky - Journal of addiction …, 2019 - journals.lww.com
… On the basis of results of this study and a previously reported pivotal trial ( Gorodetzky et
al., 2017 ), the FDA approved lofexidine in May 2018 with an indication for mitigation of …

[PDF][PDF] Oxymorphone metabolism and urinary excretion in human, rat, guinea pig, rabbit, and dog

…, WD Darwin, WF Buchwald, CW Gorodetzky - Drug Metab …, 1983 - docketalarm.com
Gorodetzky, and SY Yeh: The urinary excretion profile of naltrexone and metabolites in
man… Gorodetzky, Urinary excretion of hydromorphone and metabolites in humans, rats, dogs, …

Urinary excretion of hydromorphone and metabolites in humans, rats, dogs, guinea pigs, and rabbits

…, BA Phelps, CW Gorodetzky - Journal of Pharmaceutical …, 1977 - Wiley Online Library
Hydromorphone was administered as a single dose to humans, rats, dogs, guinea pigs, and
rabbits, and timed urinary collections were made. GLC‐mass spectrometric and GLC …

Psychometric evaluation of the 10-item Short Opiate Withdrawal Scale-Gossop (SOWS-Gossop) in patients undergoing opioid detoxification

…, S Reinders, S Mannix, K Gullo, CW Gorodetzky… - Addictive …, 2016 - Elsevier
Gorodetzky contributed to the design of the study and reviewed and contributed to the
final manuscript. Thomas Clinch contributed to the design of the statistical analysis plan, …

An experimental study in the treatment of narcotic addicts with cyclazocine

WR Martin, CW Gorodetzky… - Clinical Pharmacology & …, 1966 - Wiley Online Library
The potent narcotic antagonist, cyclazocine, has a long duration of action and is effective
when administered orally. Although tolerance develops to many of the effects of cyclazocine, …