A pharmacokinetic profile of tomoxetine, a selective norepinephrine uptake inhibitor, was
developed in human volunteers following single and multiple oral administrations. Following …

Rats and guinea pigs dosed with dl-6-chlorotryptophan or d-6-chlorotryptophan excrete
significantly greater amounts of 3-hydroxyanthranilic acid in the urine than do animals treated …

… at 37-38’C with a heating … at 37’C before being pipetted … 20 mm at 37’C, and 200 zl
of sample …

The oxidation of d-amphetamine by rabbit liver microsomes has been studied using oxygen-18
as the source of oxygen. Incorporation of heavy oxygen into the two major metabolites …

A stereospecific HPLC assay has been developed for the determination of the enantiomers
of fluoxetine and an active metabolite, norfluoxetine, in plasma and tissue. Following …

Axelmod (I) first described the microsomal oxidation of primary amines in 1955. He reported
that amphetamine and related primary amines are oxidized in rabbit liver microsomes, …

Brain 5-hydroxyindole levels were measured 6 hr after the ip injection of 4-chloroamphetamine
and two of its possible metabolites—the oxime and the hydroxylamine. Both 4-…

The major In vlvo human metabolfte of zatosetron is 8-a-methyl, 8-$-oxo zatosetron[NC (1)
zatosetron]. N-Desmethyl zatosetron(NdM zatosetron) and 3-hydroxy-zatosetron(3-OH-…

8B-N-cyclohexyl-6-methyl-1-(1-methylethyl) ergoline-8-carboxamide (LY237733) is an
ergoline with potent and highly selective 5-hydroxytryptamine(5-HI) antagonist activity. The in …

The induction of the microsomal hemoproteins, cytochromes P-450 and Pi-450, and of N-demethylase
activities in hepatic microsomal subfractions from rats were studied at various …