Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …

A 25-year computerised survey of deaths in the United Kingdom among diabetic patients of
19 years of age and under was performed. Suitable pancreatic material was available in 119 …

… Loss of ATP8B1 results in reduced activity and nuclear translocation of FXR which is caused
by impaired protein kinase C zeta (PKCzeta)-mediated phosphorylation of FXR. Negative …

Nonalcoholic steatohepatitis (NASH) is often linked with disorders that are clearly associated
with insulin resistance (IR): obesity, type 2 diabetes mellitus, and hypertriglyceridemia. We …

The circadian clock acts at the genomic level to coordinate internal behavioural and
physiological rhythms via the CLOCK–BMAL1 transcriptional heterodimer. Although the nuclear …

Nonalcoholic steatohepatitis (NASH) has multiple etiologic associations, but the pathogenesis
is poorly understood. Cytochrome P450 (CYP) 2E1 is induced in the liver of patients who …

The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) is attributed to
intrinsic chemoresistance and a growth-permissive tumor microenvironment. Conversion of …

… Cells were grown at 25 C in LB medium with 0.1 mg/ml carbenicillin for approximately 20 h
before harvesting. Routinely, 60–70 g of cell paste were resuspended in 400–450 ml of TBS (…

Liver fibrosis is a reversible wound-healing response involving TGFβ1/SMAD activation of
hepatic stellate cells (HSCs). It results from excessive deposition of extracellular matrix …

Cytochrome P-450 3A4 (CYP3A4), the predominant cytochrome P-450 expressed in adult
human liver, is subject to transcriptional induction by a variety of structurally unrelated …