St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
…, GB Wisely, CJ Serabjit-Singh… - Proceedings of the …, 2000 - National Acad Sciences
St. John's wort (Hypericum perforatum) is an herbal remedy used widely for the treatment of
depression. Recent clinical studies demonstrate that hypericum extracts increase the …
depression. Recent clinical studies demonstrate that hypericum extracts increase the …
Rational use of in vitro P-glycoprotein assays in drug discovery
…, JB Morgan, LO Webster, CS Serabjit-Singh - … of Pharmacology and …, 2001 - ASPET
… MB is calculated with the following equation: MB = [(C At ∗V A ) + (C Bt ∗V B )]/(C 0 ∗V D
), where C At andC Bt are the concentrations in the A and B chambers at time (t),C 0 is the …
), where C At andC Bt are the concentrations in the A and B chambers at time (t),C 0 is the …
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs
…, SA Wring, LJ Shampine, CJ Serabjit-Singh… - … of Pharmacology and …, 2002 - ASPET
… where C At andC Bt are the drug concentrations in the apical (A) and basolateral (B) chambers
at time (t),C 0 is the concentration of the donor at time 0, V A andV B are the volumes of …
at time (t),C 0 is the concentration of the donor at time 0, V A andV B are the volumes of …
In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates
…, JP Keogh, JR Kunta, CJ Serabjit-Singh… - Drug metabolism and …, 2006 - ASPET
… where C At and C Bt are the drug concentrations in the A and B chambers at time (t), C 0 is
the concentration of the donor at time 0, V A and V B are the volumes of the A and B chambers…
the concentration of the donor at time 0, V A and V B are the volumes of the A and B chambers…
The role of efflux and uptake transporters in N-{3-chloro-4-[(3-fluorobenzyl) oxy] phenyl}-6-[5-({[2-(methylsulfonyl) ethyl] amino} methyl)-2-furyl]-4-quinazolinamine …
…, LS John-Williams, KM Koch, CJ Serabjit-Singh - Drug metabolism and …, 2008 - ASPET
… was added, and the cells were incubated at 37C for 5 min. The inhibitor solution was removed,
cells were rinsed three times using 800 μl of cold (4C) DPBS and lysed with 400 μl of 1% (…
cells were rinsed three times using 800 μl of cold (4C) DPBS and lysed with 400 μl of 1% (…
Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans.
CM Dixon, PV Colthup, CJ Serabjit-Singh… - Drug metabolism and …, 1995 - ASPET
Ondansetron is cleared primarily by metabolism in humans, with hydroxylation of the indole
moiety in the 7- and 8-positions being the major identified phase I pathways. In vitro studies …
moiety in the 7- and 8-positions being the major identified phase I pathways. In vitro studies …
Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors
…, JL Woolley, KR Brouwer, C Serabjit-Singh… - Drug metabolism and …, 2001 - ASPET
… Similarly, the plasma concentration of nelfinavir at 1 h after the last dose (C max ) was
reduced by 52% after multiple doses. Compared with controls, dosing of amprenavir for 14 days …
reduced by 52% after multiple doses. Compared with controls, dosing of amprenavir for 14 days …
Drug interactions with herbal products and grapefruit juice: a conference report
…, P Watkins, LA Love, C Serabjit‐Singh… - Clinical …, 2004 - Wiley Online Library
In the United States 60 million Americans use alternative ways to heal and 1 in 3 use some
form of complementary or alternative medicine. 1-3 Herbal supplements are used by 14% of …
form of complementary or alternative medicine. 1-3 Herbal supplements are used by 14% of …
Predicting P-glycoprotein substrates by a quantitative structure–activity relationship model
…, JE Humphreys, SA Wring, CS Serabjit-Singh - Journal of …, 2004 - Elsevier
… Similarly, a higher ES of a N atom with zero hydrogens (E_N) and a higher number of the
O‐C hydrides (Q_O‐C) increases the probability of a compound to be a non‐substrate. …
O‐C hydrides (Q_O‐C) increases the probability of a compound to be a non‐substrate. …
The pulmonary uptake, accumulation, and metabolism of xenobiotics
JR Bend, CJ Serabjit-Singh… - Annual review of …, 1985 - annualreviews.org
… removal of the endothelium (CJ Serabjit-Singh, JR Bend, RM … c) in the microsomal fractions
of both intact rabbit aorta (54) and aorta after removing the endothelium (CJ Serabjit-Singh, …
of both intact rabbit aorta (54) and aorta after removing the endothelium (CJ Serabjit-Singh, …