User profiles for C. Vens

Celine Vens

professor, Katholieke Universiteit Leuven
Verified email at kuleuven.be
Cited by 3407

Strategies to improve radiotherapy with targeted drugs

AC Begg, FA Stewart, C Vens - Nature Reviews Cancer, 2011 - nature.com
Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success.
The dose of ionizing radiation that can be given to the tumour is determined by the …

Decision trees for hierarchical multi-label classification

C Vens, J Struyf, L Schietgat, S Džeroski, H Blockeel - Machine learning, 2008 - Springer
… To construct the tree for class c with such a learner, we label the class c examples positive
and all the other examples negative. The resulting tree predicts the probability that a new …

Predicting human olfactory perception from chemical features of odor molecules

…, JD Mainland, Y Ihara, CW Yu, R Wolfinger, C Vens… - Science, 2017 - science.org
It is still not possible to predict whether a given molecule will have a perceived odor or what
olfactory percept it will produce. We therefore organized the crowd-sourced DREAM …

Tree ensembles for predicting structured outputs

D Kocev, C Vens, J Struyf, S Džeroski - Pattern Recognition, 2013 - Elsevier
In this paper, we address the task of learning models for predicting structured outputs. We
consider both global and local predictions of structured outputs, the former based on a single …

Ensembles of multi-objective decision trees

D Kocev, C Vens, J Struyf, S Džeroski - Machine Learning: ECML 2007 …, 2007 - Springer
Ensemble methods are able to improve the predictive performance of many base classifiers.
Up till now, they have been applied to classifiers that predict a single target attribute. Given …

[HTML][HTML] Predicting gene function using hierarchical multi-label decision tree ensembles

L Schietgat, C Vens, J Struyf, H Blockeel, D Kocev… - BMC …, 2010 - Springer
… We will first investigate if ensembles improve the predictive performance of CLUS-HMC
in gene function prediction and if so, quantify this difference. We will then compare …

[HTML][HTML] Homologous Recombination Deficiency Scar: Mutations and Beyond—Implications for Precision Oncology

…, Y Cong, J Theys, A Van Hoeck, C Vens… - Cancers, 2022 - mdpi.com
Simple Summary A characteristic across several cancer types is a homologous recombination
deficiency (HRD). HRD is associated with a better response to several anticancer …

Novel therapeutics in combination with radiotherapy to improve cancer treatment: rationale, mechanisms of action and clinical perspective

M Verheij, C Vens, B van Triest - Drug Resistance Updates, 2010 - Elsevier
Our increased understanding of the molecular processes underlying cellular sensitivity to
ionizing radiation has led to the identification of novel targets for intervention. New agents have …

T cell activation responses are differentially regulated during clinorotation and in spaceflight

BB Hashemi, JE Penkala, C Vens, H Huls… - The FASEB …, 1999 - Wiley Online Library
Studies of T lymphocyte activation with mitogenic lectins during spaceflight have shown a
dramatic inhibition of activation as measured by DNA synthesis at 72 h, but the mechanism of …

Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of …

…, M Verheij, MW van den Brekel, C Vens - Radiotherapy and …, 2015 - Elsevier
Background and purpose The PARP inhibitor olaparib is currently tested in clinical phase 1
trials to define safe dose levels in combination with RT. However, certain clinically relevant …