Evaluation of ketoconazole and its alternative clinical CYP3A4/5 inhibitors as inhibitors of drug transporters: the in vitro effects of ketoconazole, ritonavir, clarithromycin …

LMM Vermeer, CD Isringhausen, BW Ogilvie… - Drug metabolism and …, 2016 - ASPET
Ketoconazole is a potent CYP3A4/5 inhibitor and, until recently, recommended by the Food
and Drug Administration (FDA) and the European Medicines Agency as a strong CYP3A4/5 …

In vitro studies with two human organic anion transporters: OAT2 and OAT7

…, T Sarashina, K Hashizume, CD Isringhausen… - Xenobiotica, 2018 - Taylor & Francis
Penciclovir, ganciclovir, creatinine, para-aminohippuric acid (PAH), ketoprofen, estrone 3-O-sulfate
(E3S), dehydroepiandrosterone 3-O-sulfate (DHEAS) and cyclic guanosine …

[PDF][PDF] P151

LM Vermeer, CD Isringhausen, K Freeman, C Black… - xenotech.com
Drug-induced liver injury (DILI) is characterized as liver injury due to intake of medications
or xenobiotics, which leads to liver abnormalities or dysfunction. 1 There are a large number …

[PDF][PDF] Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Major Drug Uptake Transporters

AR Wolff, C Isringhausen, J Widmer… - Drug Metabolism …, 2015 - researchgate.net
Transporters are membrane-bound proteins that can influence the pharmacokinetic properties
of drugs. Compounds that are inhibitors of these transporters may be involved in clinically …

[PDF][PDF] Al-Zarqawi killed in Baghdad air raid

S Burwick - 2006 - Citeseer
A group of about 60 Marines with Lima Company, Third Battalion, 24th Regiment gathered
with families and friends Wednesday at the Marine Corps Reserve building in Gray before …

[BOOK][B] Immaculate: A History of Perfect Innings in Baseball

J Cairney - 2015 - books.google.com
Getting 3 batters out in order on nine pitches is one of the most remarkable feats in baseball.
Since the late 1800s, only 71 pitchers have been able to do it. Yet, unlike other rare …

[PDF][PDF] The Daily Egyptian, September 24, 2012

DE Staff - opensiuc.lib.siu.edu
An organization that helps children abroad upheld one of its mottos through an event Saturday:
think globally, act locally. For Kids’ Sake held its second annual run/walk-a-thon to raise …

[PDF][PDF] EastErn nEws

M Tkacy - 2010 - core.ac.uk
… Sometimes I think I’d have an easier time trying to learn Chinese than algebra. When I was
working on my associate’s degree at Lake Land College, I knew I had to take at least one …

[BOOK][B] 3 Nights in August: Strategy, Heartbreak, and Joy Inside the Mind of a Manager

B Bissinger - 2006 - books.google.com
This inside view with the Cardinals’ Tony La Russa by the# 1 New York Times–bestselling
author of Friday Night Lights “should appeal to any baseball fan”(Publishers Weekly). A …

[PDF][PDF] Forum discusses art facilities

M Nielsen - 2002 - core.ac.uk
Eastern students and faculty will enjoy a performance by Dale K, a comedic hypnotist,
tonight in the Grand Ballroom. The show begins at 8 pm and will be “crazy and memorable,” …