Dose-and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells
CB Lambert, C Spire, N Claude, A Guillouzo - Toxicology and applied …, 2009 - Elsevier
Phenobarbital (PB) induces or represses a wide spectrum of genes in rodent liver. Much
less is known about its effects in human liver. We used pangenomic cDNA microarrays to …
less is known about its effects in human liver. We used pangenomic cDNA microarrays to …
[HTML][HTML] Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in human hepatocytes
A Rogue, C Lambert, R Jossé, S Antherieu, C Spire… - PloS one, 2011 - journals.plos.org
Background Several glitazones (PPARγ agonists) and glitazars (dual PPARα/γ agonists)
have been developed to treat hyperglycemia and, simultaneously, hyperglycemia and …
have been developed to treat hyperglycemia and, simultaneously, hyperglycemia and …
Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells
A Rogue, C Lambert, C Spire, N Claude… - Drug Metabolism and …, 2012 - ASPET
Interindividual variations in functions other than drug metabolism activity, remain poorly
elucidated in human liver. In the present study, the whole transcriptome of several human …
elucidated in human liver. In the present study, the whole transcriptome of several human …
Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells
J Dumont, R Jossé, C Lambert, S Anthérieu… - Toxicology and applied …, 2010 - Elsevier
Human exposure to heterocyclic aromatic amines (HAA) usually occurs through mixtures
rather than individual compounds. However, the toxic effects and related mechanisms of co-…
rather than individual compounds. However, the toxic effects and related mechanisms of co-…
Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines
J Dumont, R Jossé, C Lambert, S Anthérieu… - Toxicology and applied …, 2010 - Elsevier
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline
(MeIQx) are two of the most common heterocyclic aromatic amines (HAA) …
(MeIQx) are two of the most common heterocyclic aromatic amines (HAA) …
Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part II: Performances of the In Vitro Micronucleus Test Compared to the Mouse …
E Lorge, C Lambert, V Gervais… - Toxicological …, 2007 - academic.oup.com
The in vitro micronucleus test is commonly used in the early stages of pharmaceutical
development as a predictive tool for the regulatory mouse lymphoma assay or in vitro chromosome …
development as a predictive tool for the regulatory mouse lymphoma assay or in vitro chromosome …
Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions
CB Lambert, C Spire, MP Renaud, N Claude… - Toxicology in vitro, 2009 - Elsevier
The use of in vitro human liver cell models is an attractive approach in toxicogenomic studies
designed to analyze gene expression changes induced by a toxic chemical. However, in …
designed to analyze gene expression changes induced by a toxic chemical. However, in …
3 GS/s 7 GHz BW 12 Bit MuxDAC for direct microwave signal generation over L, S or C bands
…, E Dumaine, C Lambert… - 2011 IEEE …, 2011 - ieeexplore.ieee.org
In advanced applications such as digital radar, frequency hopping encryption data links,
Micro-Wave Waveform Design Systems, Ultra Wide Bandwidth communications and software …
Micro-Wave Waveform Design Systems, Ultra Wide Bandwidth communications and software …
[PDF][PDF] Performances of the In vitro Micronucleus Test Compared to the Mouse Lymphoma Assay and the In Vitro Chromosome Aberration Assay
E Lorge, C Lambert, V Gervais, N Becourt-Lhote… - Toxicol Sci, 2006 - Citeseer
The in vitro micronucleus test is commonly used in the early stages of pharmaceutical
development as a predictive tool for the regulatory mouse lymphoma assay or in vitro chromosome …
development as a predictive tool for the regulatory mouse lymphoma assay or in vitro chromosome …
[PDF][PDF] Challenges of Mixed Signal Space grade ICs operating at Microwave frequencies.
N Chantier, B Dervaux, C Lambert, V Monier, C Allene… - 2012 - microelectronics.esa.int
When developing space grade mixed signal ICs such as data converters operating at Microwave
frequencies, significant challenges appear during the silicon design part of the project. …
frequencies, significant challenges appear during the silicon design part of the project. …