The specific cytochrome P450 (P450) isoforms mediating the biotransformations of
clobazam (CLB) and those of its major metabolites, N-desmethylclobazam (NCLB) and 4′-…

A metabolic interaction between stiripentol (STP), an anticonvulsant agent that inhibits the
activity of several cytochromes P450 (P450s), and clobazam (CLB), a 1,5-benzodiazepine, …

The efficacy of drugs acting within lymphocytes, like antiretroviral drugs in the treatment of
HIV infection, depends on their intracellular concentrations modulated by efflux proteins like …

OBJECTIVE: Given the lack of data regarding the use of oseltamivir (Tamiflu) during
pregnancy, we aimed to evaluate the placental transfer of oseltamivir phosphate and its active …

Importance of the field: ATP-binding cassette (ABC) transporters are a superfamily of efflux
pumps that transport numerous compounds across cell membranes. These transporters are …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Lopinavir/ritonavir pharmacokinetics
have been fully investigated in adults and children. WHAT THIS STUDY ADDS • Lopinavir/…

Background The aim was to evaluate the readability of research information leaflets (RIL)
for minors asked to participate in biomedical research studies and to assess the factors …

Placental transfer of the HIV integrase inhibitor raltegravir (RLT) was investigated in term
human cotyledons in the maternal-to-fetal (n = 3) and fetal-to-maternal (n = 6) directions. In the …

Human bocavirus (HBoV) has recently been described as a common agent of acute upper
and lower respiratory tract infections in children. We screened by polymerase chain reaction …

The efficacy of drugs acting on lymphocytes like anticancer, immunosuppressive, and
antiretroviral drugs depends on their intracellular concentrations, which could be modulated by …