User profiles for Cathryn Hogarth
Cathryn HogarthLa Trobe University Verified email at latrobe.edu.au Cited by 2597 |
[HTML][HTML] The key role of vitamin A in spermatogenesis
CA Hogarth, MD Griswold - The Journal of clinical …, 2010 - Am Soc Clin Investig
Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm
production. Vertebrate testes are arranged into recurring cellular associations that vary with …
production. Vertebrate testes are arranged into recurring cellular associations that vary with …
Initiating meiosis: the case for retinoic acid
The requirement for vitamin A in reproduction and development was first determined from
studies of nutritional deficiencies. Subsequent research has shown that embryonic …
studies of nutritional deficiencies. Subsequent research has shown that embryonic …
[HTML][HTML] Retinoic acid activates two pathways required for meiosis in mice
In all sexually reproducing organisms, cells of the germ line must transition from mitosis to
meiosis. In mice, retinoic acid (RA), the extrinsic signal for meiotic initiation, activates …
meiosis. In mice, retinoic acid (RA), the extrinsic signal for meiotic initiation, activates …
[HTML][HTML] Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse
…, EP Kaye, BD Keiper, CA Hogarth… - Developmental …, 2015 - Elsevier
In the testis, a subset of spermatogonia retains stem cell potential, while others differentiate
to eventually become spermatozoa. This delicate balance must be maintained, as defects …
to eventually become spermatozoa. This delicate balance must be maintained, as defects …
Processive pulses of retinoic acid propel asynchronous and continuous murine sperm production
CA Hogarth, S Arnold, T Kent, D Mitchell… - Biology of …, 2015 - academic.oup.com
The asynchronous cyclic nature of spermatogenesis is essential for continual sperm production
and is one of the hallmarks of mammalian male fertility. While various mRNA and protein …
and is one of the hallmarks of mammalian male fertility. While various mRNA and protein …
Turning a spermatogenic wave into a tsunami: synchronizing murine spermatogenesis using WIN 18,446
CA Hogarth, R Evanoff, D Mitchell, T Kent… - Biology of …, 2013 - academic.oup.com
The BDADs (bis-[dichloroacetyl]-diamines) are compounds that can inhibit spermatogenesis
via blocking the metabolism of vitamin A. We utilized one specific BDAD, WIN 18,446, to …
via blocking the metabolism of vitamin A. We utilized one specific BDAD, WIN 18,446, to …
Intact piRNA pathway prevents L1 mobilization in male meiosis
…, N Vanden Berg, CA Hogarth… - Proceedings of the …, 2017 - National Acad Sciences
The PIWI-interacting RNA (piRNA) pathway is essential for retrotransposon silencing. In
piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and …
piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and …
Genomic evidence for the absence of a functional cholesteryl ester transfer protein gene in mice and rats
CA Hogarth, A Roy, DL Ebert - … and Physiology Part B: Biochemistry and …, 2003 - Elsevier
Mice and rats are naturally deficient in cholesteryl ester transfer protein (CETP) activity,
although the reason behind the deficiency in activity is unknown. A search of mouse genome …
although the reason behind the deficiency in activity is unknown. A search of mouse genome …
Importin α mRNAs have distinct expression profiles during spermatogenesis
CA Hogarth, S Calanni, DA Jans… - … dynamics: an official …, 2006 - Wiley Online Library
Importin proteins control access to the cell nucleus by mediating the nuclear transport of
specific cargoes. We hypothesized that developmental regulation of gene expression may be …
specific cargoes. We hypothesized that developmental regulation of gene expression may be …
[HTML][HTML] Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations
Retinoic acid (RA), the active metabolite of vitamin A, is required for spermatogenesis and
many other biological processes. RA formation requires irreversible oxidation of retinal to RA …
many other biological processes. RA formation requires irreversible oxidation of retinal to RA …