User profiles for Cathryn Hogarth

Cathryn Hogarth

La Trobe University
Verified email at latrobe.edu.au
Cited by 2597

[HTML][HTML] The key role of vitamin A in spermatogenesis

CA Hogarth, MD Griswold - The Journal of clinical …, 2010 - Am Soc Clin Investig
Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm
production. Vertebrate testes are arranged into recurring cellular associations that vary with …

Initiating meiosis: the case for retinoic acid

MD Griswold, CA Hogarth, J Bowles… - Biology of …, 2012 - academic.oup.com
The requirement for vitamin A in reproduction and development was first determined from
studies of nutritional deficiencies. Subsequent research has shown that embryonic …

[HTML][HTML] Retinoic acid activates two pathways required for meiosis in mice

…, YQS Soh, ME Gill, ML Goodheart, CA Hogarth… - PLoS …, 2014 - journals.plos.org
In all sexually reproducing organisms, cells of the germ line must transition from mitosis to
meiosis. In mice, retinoic acid (RA), the extrinsic signal for meiotic initiation, activates …

[HTML][HTML] Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse

…, EP Kaye, BD Keiper, CA Hogarth… - Developmental …, 2015 - Elsevier
In the testis, a subset of spermatogonia retains stem cell potential, while others differentiate
to eventually become spermatozoa. This delicate balance must be maintained, as defects …

Processive pulses of retinoic acid propel asynchronous and continuous murine sperm production

CA Hogarth, S Arnold, T Kent, D Mitchell… - Biology of …, 2015 - academic.oup.com
The asynchronous cyclic nature of spermatogenesis is essential for continual sperm production
and is one of the hallmarks of mammalian male fertility. While various mRNA and protein …

Turning a spermatogenic wave into a tsunami: synchronizing murine spermatogenesis using WIN 18,446

CA Hogarth, R Evanoff, D Mitchell, T Kent… - Biology of …, 2013 - academic.oup.com
The BDADs (bis-[dichloroacetyl]-diamines) are compounds that can inhibit spermatogenesis
via blocking the metabolism of vitamin A. We utilized one specific BDAD, WIN 18,446, to …

Intact piRNA pathway prevents L1 mobilization in male meiosis

…, N Vanden Berg, CA Hogarth… - Proceedings of the …, 2017 - National Acad Sciences
The PIWI-interacting RNA (piRNA) pathway is essential for retrotransposon silencing. In
piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and …

Genomic evidence for the absence of a functional cholesteryl ester transfer protein gene in mice and rats

CA Hogarth, A Roy, DL Ebert - … and Physiology Part B: Biochemistry and …, 2003 - Elsevier
Mice and rats are naturally deficient in cholesteryl ester transfer protein (CETP) activity,
although the reason behind the deficiency in activity is unknown. A search of mouse genome …

Importin α mRNAs have distinct expression profiles during spermatogenesis

CA Hogarth, S Calanni, DA Jans… - … dynamics: an official …, 2006 - Wiley Online Library
Importin proteins control access to the cell nucleus by mediating the nuclear transport of
specific cargoes. We hypothesized that developmental regulation of gene expression may be …

[HTML][HTML] Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations

SL Arnold, T Kent, CA Hogarth, S Schlatt, B Prasad… - Journal of lipid …, 2015 - ASBMB
Retinoic acid (RA), the active metabolite of vitamin A, is required for spermatogenesis and
many other biological processes. RA formation requires irreversible oxidation of retinal to RA …