Tolvaptan for improvement of hepatic edema: a phase 3, multicenter, randomized, double‐blind, placebo‐controlled trial

…, S Kawazoe, K Kajimura, T Saito, C Okuse… - Hepatology …, 2014 - Wiley Online Library
Aim Hepatic edema is manifested by ascites, lower limb edema and intolerable symptoms.
Some patients insufficiently respond to the conventional diuretic therapy. Therefore, a novel …

Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase of genotype A

…, S Kawata, E Tanaka, N Izumi, C Okuse… - Journal of clinical …, 2009 - Am Soc Microbiol
Acute hepatitis B virus (HBV) infection has been increasing through promiscuous sexual
contacts, and HBV genotype A (HBV/A) is frequent in patients with acute hepatitis B (AHB) in …

Higher discontinuation and lower survival rates are likely in elderly Japanese patients with advanced hepatocellular carcinoma receiving sorafenib

…, S Kobayashi, S Ohkawa, C Okuse… - Hepatology …, 2011 - Wiley Online Library
Aim: Sorafenib is approved for the treatment of advanced hepatocellular carcinoma (HCC)
in Japan; however, its tolerability and efficacy in elderly patients with HCC have not been …

[HTML][HTML] Pancreatic involvement in chronic viral hepatitis

…, K Hashizume, C Okuse, N Okuse… - World Journal of …, 2005 - ncbi.nlm.nih.gov
AIM: To elucidate the frequency and characteristics of pancreatic disorders in the course of
chronic viral hepatitis. METHODS: We prospectively assessed the serum pancreatic enzyme …

Insufficient radiofrequency ablation therapy may induce further malignant transformation of hepatocellular carcinoma

…, Y Katakura, K Matsunaga, T Ishii, C Okuse… - Hepatology …, 2008 - Springer
Background Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a
thermoablative technique to kill tumor tissue by generating areas of coagulative necrosis. Recent …

[HTML][HTML] Randomized, phase II trial of sequential hepatic arterial infusion chemotherapy and sorafenib versus sorafenib alone as initial therapy for advanced …

…, T Hatanaka, D Takizawa, K Matsunaga, C Okuse… - BMC cancer, 2019 - Springer
Background The efficacy of hepatic arterial infusion chemotherapy (HAIC) for advanced
hepatocellular carcinoma (HCC) remains unclear. We conducted a multi-center randomized …

[HTML][HTML] Risk factors for retinopathy associated with interferon α-2b and ribavirin combination therapy in patients with chronic hepatitis C

C Okuse, H Yotsuyanagi, Y Nagase… - World Journal of …, 2006 - ncbi.nlm.nih.gov
AIM: To elucidate the frequency and risk factors for retinopathy in patients with chronic
hepatitis C who are treated by interferon-ribavirin combination therapy. METHODS: We …

[HTML][HTML] Modified response evaluation criteria in solid tumors is superior to response evaluation criteria in solid tumors for assessment of responses to sorafenib in …

…, K Numata, K Tanaka, K Matsunaga, C Okuse… - BMC Research …, 2015 - Springer
Background Modified response evaluation criteria in solid tumors (mRECIST) and RECIST
are used to assess the effect of treatment with targeted agents for hepatocellular carcinoma (…

[HTML][HTML] Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis

…, K Matsunaga, N Matsumoto, C Okuse… - World Journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To elucidate the correlation between hepatic blood flow and liver function in alcoholic
liver cirrhosis (AL-LC). METHODS: The subjects included 35 patients with AL-LC (34 men, 1 …

Distinct geographic distributions of hepatitis B virus genotypes in patients with acute infection in Japan

H Yotsuyanagi, C Okuse, K Yasuda… - Journal of medical …, 2005 - Wiley Online Library
Genotypes of hepatitis B virus (HBV) were determined in 145 patients with acute hepatitis B
from various districts in Japan to establish their geographic distribution and evaluating the …