Aldehyde oxidase (AO) metabolism could lead to significant underestimation of clearance in
prediction of human pharmacokinetics as well as unanticipated exposure to AO-generated …

Accurate prediction of human pharmacokinetics (PK) remains one of the key objectives of
drug metabolism and PK (DMPK) scientists in drug discovery projects. This is typically …

Discovery efforts leading to the identification of ervogastat (PF-06865571), a systemically
acting diacylglycerol acyltransferase (DGAT2) inhibitor that has advanced into clinical trials for …

In vitro–in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog
was established using the hepatocyte relay method to support high-confidence prediction of …

In the filamentous cyanobacterium Anabaena sp. PCC 7120 patS and hetN suppress the
differentiation of vegetative cells into nitrogen‐fixing heterocysts to establish and maintain a …

The discovery of D1 subtype-selective agonists with drug-like properties has been an
enduring challenge for the greater part of 40 years. All known D1-selective agonists are …

Diacylglycerol O-acyltransferase 2 (DGAT2) inhibitors have been shown to lower liver
triglyceride content and are being explored clinically as a treatment for non-alcoholic …

The hetR, patA, hetN, and patS genes are part of a regulatory network that regulates the
differentiation and patterning of heterocysts in the filamentous cyanobacterium Anabaena sp. …

Volume of distribution at steady state (V ss ) is an important pharmacokinetic parameter of a
drug candidate. In this study, V ss prediction accuracy was evaluated by using: (1) seven …

Drug interactions involving the inhibition of hepatic organic anion transporting polypeptides (OATPs)
1B1 and OATP1B3 are considered important. Therefore, we sought to study various …