User profiles for Christopher C. Marohnic
 | Christopher C. MarohnicAbbott Laboratories Verified email at abbott.com Cited by 805 |
Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency
NADPH-cytochrome P450 oxidoreductase (CYPOR) is essential for electron donation to
microsomal cytochrome P450-mediated monooxygenation in such diverse physiological …
microsomal cytochrome P450-mediated monooxygenation in such diverse physiological …
The Structure and Biochemistry of NADH-Dependent Cytochrome b5 Reductase Are Now Consistent
MC Bewley, CC Marohnic, MJ Barber - Biochemistry, 2001 - ACS Publications
Cytochrome b 5 reductase (cb5r) (EC 1.6.6.2) catalyzes the reduction of two molecules of
cytochrome b 5 using NADH as the physiological electron donor. The structure of pig cb5r at …
cytochrome b 5 using NADH as the physiological electron donor. The structure of pig cb5r at …
[HTML][HTML] Diminished FAD binding in the Y459H and V492E Antley-Bixler syndrome mutants of human cytochrome P450 reductase
CC Marohnic, SP Panda, P Martásek… - Journal of biological …, 2006 - ASBMB
Numerous mutations/polymorphisms of the POR gene, encoding NADPH:cytochrome P450
oxidoreductase (CYPOR), have been described in patients with Antley-Bixler syndrome (ABS…
oxidoreductase (CYPOR), have been described in patients with Antley-Bixler syndrome (ABS…
Human cytochrome P450 oxidoreductase deficiency caused by the Y181D mutation: molecular consequences and rescue of defect
CC Marohnic, SP Panda, K McCammon, J Rueff… - Drug metabolism and …, 2010 - ASPET
Patients with congenital adrenal hyperplasia, exhibiting combined CYP17 and CYP21
deficiency, were shown by Arlt et al. (2004) to harbor a 541T→G mutation in exon 5 of POR (…
deficiency, were shown by Arlt et al. (2004) to harbor a 541T→G mutation in exon 5 of POR (…
Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley–Bixler syndrome variants of cytochrome P450 oxidoreductase
M Kranendonk, CC Marohnic, SP Panda… - Archives of Biochemistry …, 2008 - Elsevier
Y459H and V492E mutations of cytochrome P450 reductase (CYPOR) cause Antley–Bixler
syndrome due to diminished binding of the FAD cofactor. To address whether these …
syndrome due to diminished binding of the FAD cofactor. To address whether these …
Engineering and Characterization of a NADPH-Utilizing Cytochrome b5 Reductase
CC Marohnic, MC Bewley, MJ Barber - Biochemistry, 2003 - ACS Publications
Microsomal cytochrome b 5 reductase (EC 1.6.2.2) catalyzes the reduction of ferricytochrome
b 5 using NADH as the physiological electron donor. Site-directed mutagenesis has been …
b 5 using NADH as the physiological electron donor. Site-directed mutagenesis has been …
Altered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system
NADPH-cytochrome P450 oxidoreductase (CYPOR) variants have been described in
patients with perturbed steroidogenesis and sexual differentiation, related to Antley-Bixler …
patients with perturbed steroidogenesis and sexual differentiation, related to Antley-Bixler …
Cytochromes P450—A Family of Proteins and Scientists–Understanding their Relationships
B Sue Masters, CC Marohnic - Drug metabolism reviews, 2006 - Taylor & Francis
The unifying thread of this review involves NADPH-cytochrome P450 reductase (CYPOR), the
microsomal enzyme responsible for transferring electrons to cytochromes P450, as well as …
microsomal enzyme responsible for transferring electrons to cytochromes P450, as well as …
Measurement of membrane-bound human heme oxygenase-1 activity using a chemically defined assay system
WJ Huber, CC Marohnic, M Peters, J Alam… - Drug metabolism and …, 2009 - ASPET
Heme oxygenase (HO) catalyzes heme degradation in a reaction requiring NADPH-cytochrome
P450 reductase (CPR). Although most studies with HO used a soluble 30-kDa form, …
P450 reductase (CPR). Although most studies with HO used a soluble 30-kDa form, …
Cytochrome b5 Reductase: Role of the si-Face Residues, Proline 92 and Tyrosine 93, in Structure and Catalysis
CC Marohnic, LJ Crowley, CA Davis, ET Smith… - Biochemistry, 2005 - ACS Publications
The conserved sequence motif “RxY T S xx S N ” coordinates flavin binding in NADH:cytochrome
b 5 reductase (cb 5 r) and other members of the flavin transhydrogenase superfamily of …
b 5 reductase (cb 5 r) and other members of the flavin transhydrogenase superfamily of …