Drug-metabolizing enzymes and drug transporters are key determinants of the pharmacokinetics
and pharmacodynamics of many antineoplastic agents. Metabolism and transport …

This article is an invited report of a symposium sponsored by the Division for Drug
Metabolism of the American Society for Pharmacology and Experimental Therapeutics held at …

The anthracycline doxorubicin has little activity against colorectal cancers. It is hypothesized
that this is attributable to a multifactorial resistance mechanism in which the glutathione S-…

The cytochromes P450 are a superfamily of enzymes that can carry out a wide range of
oxidative reactions. While the transcriptional control of the cytochrome P450 genes has been …

Doxorubicin is a useful antineoplastic drug with multiple mechanisms of cytotoxicity. One
such mechanism involves the reductive bioactivation of the quinone ring to a semiquinone …

The objective of this study was to determine the effects of 5-fluorouracil (5FU) on the expression
of individual cytochrome P450 (CYP) isozymes in rat liver at the catalytic activity and …

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates
most biological responses to 2,3, 7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related …

Antisense oligodeoxynucleotides (ODNs) are designed to bind to and inhibit a target mRNA.
We used a novel approach for the design of ODNs to the c-myc mRNA using protein …

The aromatic hydrocarbon (AH) receptor mediates the induction of cytochromes P-450 (CYP)
of the CYP1A subfamily caused by polycyclic aromatic hydrocarbons (PAHs). CYPIA …

3-Methylcholanthrene (MC) activates the aryl hydrocarbon receptor and increases expression
of cytochrome P450 (P450) enzymes such as CYP1A1. MC also decreases expression of …