Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk …
…, JS Taur, D Weitz, HM Wortelboer, CQ Xia… - Drug metabolism and …, 2013 - ASPET
A P-glycoprotein (P-gp) IC 50 working group was established with 23 participating
pharmaceutical and contract research laboratories and one academic institution to assess …
pharmaceutical and contract research laboratories and one academic institution to assess …
Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes
C Lu, P Li, R Gallegos, V Uttamsingh, CQ Xia… - Drug metabolism and …, 2006 - ASPET
Apparent intrinsic clearance (CL int,app ) of 7-ethoxycoumarin, phenacetin, propranolol, and
midazolam was measured using rat and human liver microsomes and freshly isolated and …
midazolam was measured using rat and human liver microsomes and freshly isolated and …
Evaluation of drug-transporter interactions using in vitro and in vivo models
CQ Xia, MN Milton, LS Gan - Current drug metabolism, 2007 - ingentaconnect.com
Drug transporters, including efflux transporters (the ATP binding cassette (ABC) proteins)
and uptake transporters (the solute carrier proteins (SLC)), have an important impact on drug …
and uptake transporters (the solute carrier proteins (SLC)), have an important impact on drug …
Drug efflux transporters and multidrug resistance in acute leukemia: therapeutic impact and novel approaches to mediation
CQ Xia, PG Smith - Molecular pharmacology, 2012 - ASPET
Multidrug resistance (MDR), which is mediated by multiple drug efflux ATP-binding cassette
(ABC) transporters, is a critical issue in the treatment of acute leukemia, with permeability …
(ABC) transporters, is a critical issue in the treatment of acute leukemia, with permeability …
Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells
CQ Xia, N Liu, D Yang, G Miwa, LS Gan - Drug metabolism and disposition, 2005 - ASPET
The function of breast cancer resistance protein (BCRP) and its role in drug absorption,
distribution, and elimination has recently been evaluated. The objective of the present study was …
distribution, and elimination has recently been evaluated. The objective of the present study was …
Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats
CQ Xia, J Wang, WC Shen - Journal of Pharmacology and Experimental …, 2000 - ASPET
Transferrin (Tf) receptor-mediated transcytosis of insulin-transferrin conjugate (In-Tf) has
been demonstrated in cultured human enterocyte-like Caco-2 cells. In the present report, oral …
been demonstrated in cultured human enterocyte-like Caco-2 cells. In the present report, oral …
[HTML][HTML] Immunogenicity assessment of AAV-based gene therapies: an IQ consortium industry white paper
…, KG Stubenrauch, M Vinzing, CQ Xia… - … Therapy-Methods & …, 2022 - cell.com
Immunogenicity has imposed a challenge to efficacy and safety evaluation of adeno-associated
virus (AAV) vector-based gene therapies. Mild to severe adverse events observed in …
virus (AAV) vector-based gene therapies. Mild to severe adverse events observed in …
[HTML][HTML] Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development
…, X Liu, C Lu, J Mao, H Shen, H Tang, CQ Xia… - … Pharmaceutica Sinica B, 2022 - Elsevier
Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK (…
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK (…
Quantification of four efflux drug transporters in liver and kidney across species using targeted quantitative proteomics by isotope dilution NanoLC-MS/MS
Purpose The expression levels of several efflux drug transporters in the liver and kidney
were evaluated across species to address potential roles of the transporters in species …
were evaluated across species to address potential roles of the transporters in species …
Interactions of cyclosporin a with breast cancer resistance protein
CQ Xia, N Liu, GT Miwa, LS Gan - Drug metabolism and disposition, 2007 - ASPET
The objective of this study was to investigate whether cyclosporin A (CsA) is a modulator for
breast cancer resistance protein (BCRP). The interactions between CsA and BCRP were …
breast cancer resistance protein (BCRP). The interactions between CsA and BCRP were …