Determination of ondansetron in plasma and its pharmacokinetics in the young and elderly
PV Colthup, CC Felgate, JL Palmer… - Journal of pharmaceutical …, 1991 - Elsevier
Ondansetron is a 5-hydroxytryptamine 3 receptor antagonist for the treatment of chemotherapy-
and radiotherapy-induced nausea and emesis. A sensitive, accurate, and precise HPLC …
and radiotherapy-induced nausea and emesis. A sensitive, accurate, and precise HPLC …
Metabolism and disposition of vilanterol, a long-acting β2-adrenoceptor agonist for inhalation use in humans
…, J Bal, NH Patel, GC Young, CC Felgate… - Drug Metabolism and …, 2013 - ASPET
The metabolism and disposition of vilanterol, a novel long-acting β 2 -adrenoceptor agonist (LABA)
for inhalation use, was investigated after oral administration in humans. Single oral …
for inhalation use, was investigated after oral administration in humans. Single oral …
Determination of salmeterol in rat and dog plasma by high‐performance liquid chromatography with fluorescence detection
…, GC Young, CC Felgate - Journal of pharmaceutical …, 1993 - Wiley Online Library
Abstract 0 Salmeterol (as the hydroxynaphthoate) is the first of a new class of long‐acting
padrenergic receptor agonists with both bronchodilator and anti‐inflammatory actions. A …
padrenergic receptor agonists with both bronchodilator and anti‐inflammatory actions. A …
The metabolism and disposition of GSK2140944 in healthy human subjects
K Negash, C Andonian, C Felgate, C Chen, I Goljer… - Xenobiotica, 2016 - Taylor & Francis
GSK2140944 is a novel bacterial topoisomerase inhibitor in development for the treatment
of bacterial infections. The metabolism and disposition in healthy human subjects was …
of bacterial infections. The metabolism and disposition in healthy human subjects was …
An investigation of the comparability of commercially sourced plasma and pharmaceutical study plasma, using total protein concentration
C Felgate, N Spooner, R Calloway - Bioanalysis, 2016 - Future Science
Background: Control blood plasma is regularly used in bioanalysis, biomarkers and proteomics,
and is often obtained from commercial sources. It has always been assumed that this …
and is often obtained from commercial sources. It has always been assumed that this …
Investigation of metabolism and disposition of GSK1322322, a peptidase deformylase inhibitor, in healthy humans using the entero-test for biliary sampling
…, C Felgate, L Jones, P Stump, E Pierre, C Bowen… - Drug Metabolism and …, 2014 - ASPET
… In this study, we investigated the metabolism and disposition of [ 14 C]GSK1322322 in
healthy humans and demonstrated the utility of the Entero-Test in a human radiolabel study. We …
healthy humans and demonstrated the utility of the Entero-Test in a human radiolabel study. We …
Investigation of metabolism and disposition of GSK1322322, a PDF inhibitor, in healthy humans using Entero-Test® for biliary sampling
…, C Felgate, L Jones, P Stump, E Pierre, C Bowen… - Drug Metabolism and …, 2014 - ASPET
GSK1322322 is an antibiotic in development by GlaxoSmithKline. In this study, we
investigated metabolism and disposition of [ 14 C]GSK1322322 in healthy humans, and …
investigated metabolism and disposition of [ 14 C]GSK1322322 in healthy humans, and …
Solute transport via the new permeability pathways in Plasmodium falciparum–infected human red blood cells is not consistent with a simple single-channel model
HM Staines, S Ashmore, H Felgate, J Moore, T Powell… - Blood, 2006 - ashpublications.org
After infection of a red blood cell (RBC), the malaria parasite, Plasmodium falciparum, increases
the permeability of the host's plasma membrane by inducing new permeability pathways …
the permeability of the host's plasma membrane by inducing new permeability pathways …
A phase I, open-label, single-dose micro tracer mass balance study of 14C-labeled ASP7991 in healthy Japanese male subjects using accelerator mass spectrometry
D Miyatake, N Nakada, A Takada, K Kato… - Drug Metabolism and …, 2018 - Elsevier
… The mass balance and metabolite profile of [ 14 C]ASP7991 were investigated in six healthy
male subjects after a single oral dose of [ 14 C]ASP7991 [1ámg, 18.5ákBq (500ánCi)] in …
male subjects after a single oral dose of [ 14 C]ASP7991 [1ámg, 18.5ákBq (500ánCi)] in …
Pharmacokinetics and tolerability of SRT 2104, a first‐in‐class small molecule activator of SIRT 1, after single and repeated oral administration in man
…, J Wald, S Lavu, J Roberts, C Beaumont… - British Journal of …, 2013 - Wiley Online Library
Aim SRT 2104 is a novel, first‐in‐class, highly selective small molecule activator of the NAD
+ dependent deacetylase SIRT 1. SRT 2104 was dosed to healthy male and female …
+ dependent deacetylase SIRT 1. SRT 2104 was dosed to healthy male and female …