User profiles for Colin D.A. Brown
Colin DA BrownNewcells Biotech Newcastle upon Tyne Verified email at newcellsbiotech.co.uk Cited by 3814 |
Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine
…, PD Mitchell, JA Jarcho, CDA Brown… - Clinical …, 2004 - Wiley Online Library
Background Cyclosporine (INN, ciclosporin) increases the systemic exposure of all statins.
Therefore rosuvastatin pharmacokinetic parameters were assessed in an open‐label trial …
Therefore rosuvastatin pharmacokinetic parameters were assessed in an open‐label trial …
The effect of gemfibrozil on the pharmacokinetics of rosuvastatin
…, PD Martin, KC Lasseter, CDA Brown… - Clinical …, 2004 - Wiley Online Library
Background Coadministration of statins and gemfibrozil is associated with an increased risk
for myopathy, which may be due in part to a pharmacokinetic interaction. Therefore the effect …
for myopathy, which may be due in part to a pharmacokinetic interaction. Therefore the effect …
The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule
Acquiring a mechanistic understanding of the processes underlying the renal clearance of
drug molecules in man has been hampered by a lack of robust in vitro models of human …
drug molecules in man has been hampered by a lack of robust in vitro models of human …
Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling
CDA Brown, R Sayer, AS Windass, IS Haslam… - Toxicology and applied …, 2008 - Elsevier
The aim of this study was to determine whether primary human tubular cell monolayers
could provide a powerful tool with which to investigate the renal proximal tubular handling of …
could provide a powerful tool with which to investigate the renal proximal tubular handling of …
Abundance of drug transporters in the human kidney cortex as quantified by quantitative targeted proteomics
Protein expression of renal uptake and efflux transporters was quantified by quantitative
targeted proteomics using the surrogate peptide approach. Renal uptake transporters assessed …
targeted proteomics using the surrogate peptide approach. Renal uptake transporters assessed …
The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin
Rosuvastatin is a potent inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase and has been
shown to be highly effective in reducing low-density lipoprotein cholesterol. Clinical trials …
shown to be highly effective in reducing low-density lipoprotein cholesterol. Clinical trials …
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis
…, C Bragg, X Xu, GW Chung, CDA Brown… - Nature …, 2020 - nature.com
Fibrosis is a common pathological feature of chronic disease. Deletion of the NF-κB subunit
c-Rel limits fibrosis in multiple organs, although the mechanistic nature of this protection is …
c-Rel limits fibrosis in multiple organs, although the mechanistic nature of this protection is …
The organic cation transporter OCT2 mediates the uptake of β‐adrenoceptor antagonists across the apical membrane of renal LLC‐PK1 cell monolayers
…, K Bleasby, CDA Brown - British journal of …, 2000 - Wiley Online Library
Previous studies have shown that β‐adrenoceptor antagonists may be substrates of organic
cation transporters in kidney and lung. In this study we examined the transport of the β‐…
cation transporters in kidney and lung. In this study we examined the transport of the β‐…
The importance of incorporating OCT2 plasma membrane expression and membrane potential in IVIVE of metformin renal secretory clearance
Transporter expression, determined by quantitative proteomics, together with PBPK models
is a promising approach for in vitro-to-in vivo extrapolation (IVIVE) of transporter-mediated …
is a promising approach for in vitro-to-in vivo extrapolation (IVIVE) of transporter-mediated …
Microsomal and cytosolic scaling factors in dog and human kidney cortex and application for in vitro-in vivo extrapolation of renal metabolic clearance
In vitro-in vivo extrapolation of drug metabolism data obtained in enriched preparations of
subcellular fractions rely on robust estimates of physiologically relevant scaling factors for the …
subcellular fractions rely on robust estimates of physiologically relevant scaling factors for the …