Diverse applications of nanomedicine

…, LP Balogh, L Ballerini, A Bestetti, C Brendel… - ACS …, 2017 - ACS Publications
The design and use of materials in the nanoscale size range for addressing medical and
health-related issues continues to receive increasing interest. Research in nanomedicine …

Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib

…, RW Robey, T Volkmann, JF Deeken, C Brendel… - Drug Metabolism and …, 2010 - ASPET
Although the development of tyrosine kinase inhibitors (TKIs) to control the unregulated activity
of BCR-ABL revolutionized the therapy of chronic myeloid leukemia, resistance to TKIs is …

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation

…, H Raifer, B Camara, C Brendel… - Proceedings of the …, 2012 - National Acad Sciences
Follicular T-helper (T FH ) cells cooperate with GL7 + CD95 + germinal center (GC) B cells
to induce antibody maturation. Herein, we identify the transcription factor IRF4 as a T-cell …

Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2 …

Y Wang, D Cai, C Brendel, C Barett, P Erben… - Blood, 2007 - ashpublications.org
Overcoming imatinib mesylate (IM) resistance and disease persistence in patients with chronic
myeloid leukemia (CML) is of considerable importance to the issue of potential cure. Here …

Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2−/y knockout mice

GM Stettner, P Huppke, C Brendel… - The Journal of …, 2007 - Wiley Online Library
Rett syndrome (RTT) is an inborn neurodevelopmental disorder caused by mutations in the
X‐linked methyl‐CpG binding protein 2 gene (MECP2). Besides mental retardation, most …

[HTML][HTML] Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell …

…, M Schaich, C Theuser, B Mohr, C Brendel… - …, 2009 - ncbi.nlm.nih.gov
Abstract Analysis of donor chimerism is an important diagnostic tool to assess the risk of relapse
after allogeneic stem cell transplantation, especially in patients lacking a specific marker …

[HTML][HTML] Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model

C Brendel, V Belakhov, H Werner, E Wegener… - Journal of molecular …, 2011 - Springer
Thirty-five percent of patients with Rett syndrome carry nonsense mutations in the MECP2
gene. We have recently shown in transfected HeLa cells that readthrough of nonsense …

Antithetical NFAT c1–Sox2 and p53–miR200 signaling networks govern pancreatic cancer cell plasticity

…, S Vogt, I Esposito, A Schmidt, C Brendel… - The EMBO …, 2015 - embopress.org
In adaptation to oncogenic signals, pancreatic ductal adenocarcinoma ( PDAC ) cells
undergo epithelial–mesenchymal transition ( EMT ), a process combining tumor cell …

[PDF][PDF] Mutations in SLC33A1 cause a lethal autosomal-recessive disorder with congenital cataracts, hearing loss, and low serum copper and ceruloplasmin

P Huppke, C Brendel, V Kalscheuer… - The American Journal of …, 2012 - cell.com
Low copper and ceruloplasmin in serum are the diagnostic hallmarks for Menkes disease,
Wilson disease, and aceruloplasminemia. We report on five patients from four unrelated …

Good manufacturing practice-compliant animal-free expansion of human bone marrow derived mesenchymal stroma cells in a closed hollow-fiber-based bioreactor

P Nold, C Brendel, A Neubauer, G Bein… - … and biophysical research …, 2013 - Elsevier
Mesenchymal stroma cells (MSC) are increasingly recognized for various applications of cell-based
therapies such as regenerative medicine or immunomodulatory treatment strategies. …