Cytochromes P450 in the bioactivation of chemicals

C Ioannides, DF V Lewis - Current topics in medicinal chemistry, 2004 - ingentaconnect.com
The initial view that the cytochrome P450 enzyme system functions simply in the deactivation
of xenobiotics is anachronistic on the face of mounting evidence that this system can also …

Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat

…, N Kuhnert, MJ Sauer, LJ King, C Ioannides - British journal of …, 2008 - cambridge.org
Sulforaphane is a naturally occurring isothiocyanate with promising chemopreventive
activity. An analytical method, utilising liquid chromatography-MS/MS, which allows the …

Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen.

DF Lewis, C Ioannides, DV Parke - Environmental health …, 1998 - ehp.niehs.nih.gov
The importance of cytochrome P450 isoforms to species differences in the metabolism of
foreign compounds and activation of procarcinogens has been identified. The possible range of …

[BOOK][B] Enzyme systems that metabolise drugs and other xenobiotics

C Ioannides - 2002 - Wiley Online Library
… Rexdale, Ontario M9W 1L1, Canada Library of Congress Cataloging-in-Publication Data
Enzyme systems that metabolise drugs and other xenobiotics/edited by Costas Ioannides. …

[BOOK][B] Cytochromes P450: metabolic and toxicological aspects

C Ioannides - 1996 - books.google.com
Costas Ioannides. He has done a service in recognizing the need for a" niche" publication of
this sort and … Ioannides, and the subject of the dedication, Dennis Parke, a long healthy life. …

Effect of diet and nutrition on the expression of cytochromes P450

C IOANNIDES - Xenobiotica, 1999 - Taylor & Francis
The unprecedented versatility of the cytochrome (CYP) P450 system in the metabolism of
both exogenous and endogenous substrates is the characteristic that sets it aside from other …

[HTML][HTML] Induction of apoptosis and cytotoxicity by isothiocyanate sulforaphene in human hepatocarcinoma HepG2 cells

…, MD Ibrahim, N Mohd Ain, R Iori, C Ioannides… - Nutrients, 2018 - mdpi.com
Glucoraphenin, a glucosinolate present in large quantities in radish is hydrolysed by
myrosinase to form the isothiocyanate sulforaphene, which is believed to be responsible for its …

Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices

…, DFV Lewis, M Fernandez, C Ioannides - Journal of pineal …, 2001 - Wiley Online Library
The objective of the present studies was to define the enzyme systems catalysing the 6‐hydroxylation
of melatonin, by monitoring the levels of 6‐sulphatoxymelatonin in rat hepatic …

The natural chemopreventive phytochemical R‐sulforaphane is a far more potent inducer of the carcinogen‐detoxifying enzyme systems in rat liver and lung than the …

…, R Iori, C Ioannides - International journal of …, 2011 - Wiley Online Library
The chemopreventive activity of the phytochemical sulforaphane, (‐)1‐isothiocyanato‐4R‐(methylsulfinyl)‐butane,
present in cruciferous vegetables in substantial amounts in the form …

Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers

…, N Coldham, A Gielbert, MJ Sauer, C Ioannides - Cancer letters, 2009 - Elsevier
The plasma pharmacokinetic characteristics of the chemopreventive isothiocyanate sulforaphane
were determined in six human volunteers following single and repeated intake of raw …