User profiles for Crystal L. Schmerk
Crystal SchmerkResearch Manager, General Surgery, London Health Sciences Centre Verified email at lhsc.on.ca Cited by 1125 |
Hopanoid production is required for low-pH tolerance, antimicrobial resistance, and motility in Burkholderia cenocepacia
Hopanoids are pentacyclic triterpenoids that are thought to be bacterial surrogates for eukaryotic
sterols, such as cholesterol, acting to stabilize membranes and to regulate their fluidity …
sterols, such as cholesterol, acting to stabilize membranes and to regulate their fluidity …
The biochemical properties of the Francisella pathogenicity island (FPI)-encoded proteins IglA, IglB, IglC, PdpB and DotU suggest roles in type VI secretion
…, JS Ludu, RF Hare, EB Nix, CL Schmerk… - …, 2011 - microbiologyresearch.org
The Francisella pathogenicity island (FPI) encodes proteins thought to compose a type VI
secretion system (T6SS) that is required for the intracellular growth of Francisella novicida. In …
secretion system (T6SS) that is required for the intracellular growth of Francisella novicida. In …
The Francisella Pathogenicity Island Protein PdpD Is Required for Full Virulence and Associates with Homologues of the Type VI Secretion System
…, OM de Bruin, BN Duplantis, CL Schmerk… - Journal of …, 2008 - Am Soc Microbiol
Francisella tularensis is a highly infectious, facultative intracellular bacterial pathogen that is
the causative agent of tularemia. Nearly a century ago, researchers observed that tularemia …
the causative agent of tularemia. Nearly a century ago, researchers observed that tularemia …
Elucidation of the Burkholderia cenocepacia hopanoid biosynthesis pathway uncovers functions for conserved proteins in hopanoid‐producing bacteria
Hopanoids are bacterial surrogates of eukaryotic membrane sterols and among earth's most
abundant natural products. Their molecular fossils remain in sediments spanning more than …
abundant natural products. Their molecular fossils remain in sediments spanning more than …
Fexofenadine and rosuvastatin pharmacokinetics in mice with targeted disruption of organic anion transporting polypeptide 2B1
…, MJ Knauer, K Lin, SE Mansell, CL Schmerk… - Drug Metabolism and …, 2019 - ASPET
Organic anion transporting polypeptide 2B1 (OATP2B1) is a widely expressed membrane
transporter with diverse substrate specificity. In vitro and clinical studies suggest a role for …
transporter with diverse substrate specificity. In vitro and clinical studies suggest a role for …
A Francisella novicida pdpA mutant exhibits limited intracellular replication and remains associated with the lysosomal marker LAMP-1
CL Schmerk, BN Duplantis, PL Howard… - …, 2009 - microbiologyresearch.org
Several genes contained in the Francisella pathogenicity island (FPI) encode proteins needed
for intracellular growth and virulence of Francisella tularensis. The pdpA gene is the first …
for intracellular growth and virulence of Francisella tularensis. The pdpA gene is the first …
Longitudinal analysis of mucosa‐associated invariant T cells in sepsis reveals their early numerical decline with prognostic implications and a progressive loss of …
Sepsis‐elicited immunosuppression elevates the risk of secondary infections. We used a
clinically relevant mouse model and serial peripheral blood samples from patients to assess …
clinically relevant mouse model and serial peripheral blood samples from patients to assess …
[HTML][HTML] Improved MAIT cell functions following fecal microbiota transplantation for metastatic renal cell carcinoma
M Ninkov, CL Schmerk, M Moradizadeh… - Cancer Immunology …, 2023 - Springer
Strategies to modify the gut microbiome in cancer patients using fecal microbiota transplantation
(FMT) have gained momentum as a therapeutic intervention. However, how FMT …
(FMT) have gained momentum as a therapeutic intervention. However, how FMT …
Characterization of the pathogenicity island protein PdpA and its role in the virulence of Francisella novicida
CL Schmerk, BN Duplantis, D Wang… - …, 2009 - microbiologyresearch.org
Francisella tularensis is a highly virulent, intracellular pathogen that causes the disease
tularaemia. A research surrogate for F. tularensis is Francisella novicida, which causes a …
tularaemia. A research surrogate for F. tularensis is Francisella novicida, which causes a …
Burkholderia multivorans survival and trafficking within macrophages
CL Schmerk, MA Valvano - Journal of medical …, 2013 - microbiologyresearch.org
Cystic fibrosis (CF) patients are at great risk of opportunistic lung infection, particularly by
members of the Burkholderia cepacia complex (Bcc). This group of bacteria can cause damage …
members of the Burkholderia cepacia complex (Bcc). This group of bacteria can cause damage …