Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

JO Miners, DJ Birkett - British journal of clinical pharmacology, 1998 - Wiley Online Library
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug
metabolizing enzymes in humans. Substrates for CYP2C9 include fluoxetine, losartan, phenytoin, …

The use of caffeine as a metabolic probe for human drug metabolizing enzymes.

JO Miners, DJ Birkett - General pharmacology, 1996 - europepmc.org
1. Caffeine (CA) is metabolized extensively and at least 17 metabolites arising from primary
and secondary biotransformation pathways are found in urine following CA ingestion. The …

The characterization of two specific drug binding sites on human serum albumin

G Sudlow, DJ Birkett, DN Wade - Molecular pharmacology, 1975 - ASPET
The binding of a number of fluorescent probe molecules to human serum albumin (HSA) has
been studied. Small changes in the amino acid moiety of the dansylamino acids resulted in …

Further characterization of specific drug binding sites on human serum albumin

G Sudlow, DJ Birkett, DN Wade - Molecular pharmacology, 1976 - ASPET
The fluorescent probes 5-dimethylaminonaphthalene-1-sulfonamide and dansylsarcosine
function as specific markers for two distinct binding sites for anionic drugs on human serum …

The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism

…, GM Shenfleld, JO Miners, DJ Birkett… - Pharmacogenetics …, 1996 - journals.lww.com
… Miners JO, Wing LMH, Birkett DJ. Normal metabolism of debrisoquine and theophylline in a
… JO, Rees DLP, Gasser R, Meyer UA, Birkett DJ. Site directed mutation studies of human liver …

[PDF][PDF] Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.

W Tassaneeyakul, DJ Birkett, ME Veronese… - … of Pharmacology and …, 1993 - Citeseer
Kinetic and inhibitor studies using cDNA-expressed enzymes and human liver microsomes
have characterized the specificity of a range of cytochrome P450 (CYP) 1A substrate and …

Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man.

A Lelo, DJ Birkett, RA Robson… - British journal of clinical …, 1986 - Wiley Online Library
The pharmacokinetics of caffeine (CA), paraxanthine (PX), theobromine (TB) and
theophylline (TP) were studied in six healthy male volunteers after oral administration of each …

Diazepam metabolism by human liver microsomes is mediated by both S‐mephenytoin hydroxylase and CYP3A isoforms.

…, JO Miners, ME Veronese, DJ Birkett - British journal of …, 1994 - Wiley Online Library
1. The primary metabolism of diazepam was studied in human liver microsomes in order to
investigate the kinetics and to identify the cytochrome P450 (CYP) isoforms responsible for …

Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms

W Tassaneeyakul, DJ Birkett, ME McManus… - Biochemical …, 1994 - Elsevier
… Lelo A, Miners JO, Robson RA and Birkett DJ, Quantitative assessment of caffeine partial …
W, Veronese ME, Meyer UA and Birkett DJ, Identification of human liver cytochrome P450 …

Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

…, URSA MEYER, DJ BIRKETT - British journal of …, 1993 - Wiley Online Library
… 28 Veronese ME, Doecke CJ, Mackenzie PI, McManus ME, Miners JO, Rees DL, Gasser
R, Meyer UA, Birkett DJ. Site-directed mutation studies of human liver cytochrome P450 …