The normal metabolism of drugs can generate metabolites that have intrinsic chemical reactivity
towards cellular molecules, and therefore have the potential to alter biological function …

OBJECTIVES: Adenoidectomy and/or tonsillectomy are commonly performed in tertiary
pediatric hospitals for the management of obstructive sleep apnea, often in children with …

The significance of transporters in the disposition, metabolism, and elimination of drugs is
well recognized. One gap in our knowledge is a comprehensive understanding of how drug …

The Second International Transporter Consortium (ITC) Workshop was held with the purpose
of expanding on previous white‐paper recommendations, discussing recent regulatory …

Enzymes are protein catalysts that lower the energy barrier for a reaction and speed the rate
of a chemical change. The kinetics of reactions catalyzed by enzymes, as well as several …

An increased appreciation of the importance of transporter and enzyme interplay in drug
clearance and a desire to delineate these mechanisms necessitates the utilization of models …

Objectives Intracapsular tonsillectomy (tonsillotomy) has been used internationally, mainly
in the management of obstructive sleep apnoea, rather than recurrent tonsillitis, with few …

Accurate determination of rates of de novo synthesis and degradation of cytochrome P450s (P450s)
has been challenging. There is a high degree of variability in the multiple published …

… Author Contributions: Dr Tweedie had full access to all the data in the study and takes …
sis and interpretation of data: Tweedie and Lo. Drafting of the manuscript: Tweedie and Lo. …

CYP2D15 is the canine ortholog of human CYP2D6, the human CYP2D isoform involved in
the metabolism of drugs such as antiarhythmics, adrenoceptor antagonists, and tricyclic …