… Regarding the molecular mode of action of phenytoin, Smythies suggested that 1 forms an
array of molecules stacked on a d-turn segment of the proteicpart of a putative receptor site …

To determine whether the hydroxylation of 5,5-diphenylhydantoin (DPH) to 5-(4-hydroxyphenyl)-5-phenylhydantoin
(p-HPPH) occurs by an arene oxide-NIH shift process, racemic 5-(4-…

A reinvestigation of the Biltz synthesis of phenytoin was undertaken to selectively produce
the hydantoin derivative instead of a mixture of the hydantoin and the glycoluryl derivative. A …

Cancer‐related fatigue (CRF) is a serious symptom of patients with cancer and deteriorates
their daily quality of life. Whereas fatigue is a common problem in the general population, …

Background Most older people wish to age in place, for which functional status or being able
to perform activities of daily living (ADLs) is an important precondition. However, along with …

To investigate the potential involvement of an arene oxide-NIH shift pathway in the meta-
and para-hydroxylation of phenytoin, (R,S)-5-(2-deuteriophenyl)-5-phenylhydantoin (2-2H-DPH…

… HCl ) in 10.5% overall yield starting from dimethylamine‐d 6 hydrochloride. While methadone‐d
6 … A higher basicity along with a more important hydrophilicity were observed for the d 6 ‐…

Purpose Patients are often encouraged to participate in treatment decision-making. Most
studies on this subject focus on choosing between different curative treatment types. In the last …

This study investigated the early retirement intentions of 346 older Dutch employees by
extending the theory of planned behavior with anticipated work conditions. The results showed …

Background Cancer‐related fatigue (CRF) reduces quality of life and the activity level of
patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may …