Since 1990, the National Cancer Institute (NCI) has screened more than 60,000 compounds
against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory …

Paullones constitute a new family of benzazepinones with promising antitumoral properties.
They were recently described as potent, ATP‐competitive, inhibitors of the cell cycle …

… A presentation of the molecular modeling results and methods included in this paper is
accessible via the Internet from the following web site: Zaharevitz, DW; Gussio, R.; Leost, 2919 M.…

Modulating the structure and function of tubulin and microtubules is an important route to
anticancer therapeutics, and therefore, small molecules that bind to tubulin and cause mitotic …

Abstract Analysis of the National Cancer Institute Human Tumor Cell Line Anti-Cancer Drug
Screen data using the COMPARE algorithm to detect similarities in the pattern of compound …

Small molecules provide powerful tools to interrogate biological pathways but many
important pathway participants remain refractory to inhibitors. For example, Cdc25 dual-specificity …

For more than 10 years the National Cancer Institute (NCI) has tested compounds for their
ability to inhibit the growth of human tumor cell lines in culture (NCI screen). Work of Ken Paull …

The virulent spore-forming bacterium Bacillus anthracis secretes anthrax toxin composed of
protective antigen (PA), lethal factor (LF) and edema factor (EF). LF is a Zn-dependent …

Botulinum neurotoxins (BoNTs) are among the most lethal biological substances to have
been weaponized and are listed as biodefense category A agents. Currently, no small …

The potent adenosine deaminase inhibitor 2’-deoxycoformycin ((R)-3-(2-deoxy-β-i3-erthyropentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol)
inhibits the enzymic …