User profiles for D. A. Lauffenburger

Douglas Lauffenburger

MIT
Verified email at mit.edu
Cited by 62811

[HTML][HTML] Cell migration: a physically integrated molecular process

DA Lauffenburger, AF Horwitz - cell, 1996 - cell.com
Cell migration plays a central role in a wide variety of biological phenomena. In embryogenesis,
cellular migrations are a recurring theme in important morphogenic processes ranging …

Physicochemical modelling of cell signalling pathways

BB Aldridge, JM Burke, DA Lauffenburger… - Nature cell …, 2006 - nature.com
Physicochemical modelling of signal transduction links fundamental chemical and physical
principles, prior knowledge about regulatory pathways, and experimental data of various …

Cancer systems biology: a network modeling perspective

PK Kreeger, DA Lauffenburger - Carcinogenesis, 2010 - academic.oup.com
Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

Causal protein-signaling networks derived from multiparameter single-cell data

K Sachs, O Perez, D Pe'er, DA Lauffenburger… - Science, 2005 - science.org
Machine learning was applied for the automated derivation of causal influences in cellular
signaling networks. This derivation relied on the simultaneous measurement of multiple …

[HTML][HTML] Correlates of protection against SARS-CoV-2 in rhesus macaques

…, E Teow, H Andersen, MG Lewis, DA Lauffenburger… - Nature, 2021 - nature.com
Recent studies have reported the protective efficacy of both natural 1 and vaccine-induced
2 , 3 , 4 , 5 , 6 – 7 immunity against challenge with severe acute respiratory syndrome …

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

…, JC Loftus, MH Ginsberg, DA Lauffenburger… - Nature, 1997 - nature.com
Migration of cells in higher organisms is mediated by adhesion receptors, such as integrins,
that link the cell to extracellular-matrix ligands, transmitting forces and signals necessary for …

[HTML][HTML] Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

…, AG Schmidt, RK Reeves, RS Baric, DA Lauffenburger… - Nature, 2020 - nature.com
A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
may be required to end the coronavirus disease 2019 (COVID-19) pandemic 1 , 2 , 3 , 4 …

[BOOK][B] Receptors: models for binding, trafficking, and signaling

DA Lauffenburger, JJ Linderman - 1996 - books.google.com
Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical
engineering and cell biology by lucidly and practically demonstrating how a mathematical …

Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis

…, A Wells, DA Lauffenburger… - Proceedings of the …, 2006 - National Acad Sciences
Cell migration on 2D surfaces is governed by a balance between counteracting tractile and
adhesion forces. Although biochemical factors such as adhesion receptor and ligand …

Cell adhesion and motility depend on nanoscale RGD clustering

…, G Brown, DA Lauffenburger… - Journal of cell …, 2000 - journals.biologists.com
… as bond affinity is decreased (Kuo and Lauffenburger, 1993), we believe that the maximum
value of cell adhesion strength to the synthetic substrates used in the present study is limited …