It is generally accepted that there is neither a well-defined nor a consistent link between the
formation of drug−protein adducts and organ toxicity. Because the potential does exist, …

The normal metabolism of drugs can generate metabolites that have intrinsic chemical reactivity
towards cellular molecules, and therefore have the potential to alter biological function …

Odanacatib is a potent, selective, and neutral cathepsin K inhibitor which was developed to
address the metabolic liabilities of the Cat K inhibitor L-873724. Substituting P1 and …

In this study, we report the effect of methanol, dimethyl sulfoxide (DMSO), and acetonitrile
on the cytochrome P450 (P450)-mediated metabolism of several substrates in human liver …

… (Table 1), for example from 0.3701 to 0.3278 Da for the lower mass range (523 ± 50 Da)
and to 0.4022 Da for the higher mass range (790 ± 50 Da), allows for a more refined filtering of …

As domestic animals such as cat, horse, and dog increasingly become the clinical targets
for drug discovery programs, the need to understand how these animals metabolize …

The discovery of the potent and selective prostaglandin D 2 (PGD 2 ) receptor (DP)
antagonist [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3…

The cysteine protease cruzipain is essential for the viability, infectivity, and virulence of
Trypanosoma cruzi , the causative agent of Chagas disease. Thus, inhibitors of cruzipain are …

This paper describes the development of a high-throughput method for the analysis of cytochrome
P450 (CYP) inhibition assay incubation samples using laser diode thermal desorption …

Introduction: The roles of cysteine protease (CP) enzymes in the biochemistry and infectivity
of the three trypanosomal parasitic infections, Chagas' disease, leishmaniasis and human …