Our understanding of the mechanisms behind inter‐ and intra‐patient variability in drug
response is inadequate. Advances in the cytochrome P450 drug metabolizing enzyme field have …

Chronic kidney disease (CKD) is a condition that affects approximately 10% of the adult
population in developed countries. In patients with CKD adequate renal clearance is …

Organic solute flux across the basolateral and apical membranes of renal proximal tubule
cells is a key process for maintaining systemic homeostasis. It represents an important route …

Nephrotoxicity is the dose-limiting clinical adverse effect of cidofovir and adefovir, two potent
antiviral therapeutics. Because renal uptake likely plays a role in the etiology of cidofovir- …

Expression cloning in Xenopus laevisoocytes was used to isolate an organic anion transport
protein from rat kidney. A cDNA library was constructed from size-fractionated poly(A) + …

To begin to develop in vivo model systems for the assessment of the contributions of specific
organic anion transporter (OAT) family members to detoxification, development, and disease…

The human carboxylesterase 1 (CES1) gene encodes for the enzyme carboxylesterase 1, a
serine esterase governing both metabolic deactivation and activation of numerous …

… * DS Sweet and LMS Chan contributed equally to this study. … 47 Sweet DH, Pritchard
JB.The molecular biology of renal organic anion and organic cation transporters.Cell Biochem …

Gestational diabetes (GDM) results from failure of the β cells to adapt to increased metabolic
demands; however, the cause of GDM and the extremely high rate of progression to type 2 …

Exposure of the body to toxic organic anions is unavoidable and occurs from both intentional
and unintentional sources. Many hormones, neurotransmitters, and waste products of …