Oral contraceptive steroids are used by an estimated 60 to 70 million women worldwide.
Over the past 20 years there have been both case reports and clinical studies on the topic of …

There is marked variability in the extent to which the three classes of antiretroviral (ARV)
drugs bind to plasma proteins (<5 to >99%). Protease inhibitors (PIs), with the exception of …

Background HIV-1-infected patients vary considerably by their response to antiretroviral
treatment, drug concentrations in plasma, toxic events, and rate of immune recovery. This …

1. We have searched the adverse reactions register for the years 1968‐ 84 in an attempt to
evaluate data relating to reported pregnancies in women on oral contraceptive steroids (OCS…

Oral contraceptive steroids are of 2 types: oestrogens, of which ethinyloestradiol is the most
important, and progestagens, of which levonorgestrel and norethisterone are the most …

Aims To compare the inhibitory potential of the HIV protease inhibitors saquinavir, ritonavir
and indinavir against CYP1A2, CYP2C9, CYP2E1 and CYP3A4 catalysed metabolic …

Aims Chemical inhibitors of cytochrome P450 (CYP) are a useful tool in defining the role of
individual CYPs involved in drug metabolism. The aim of the present study was to evaluate …

Patients taking oral contraceptive steroids (OCS) are known to suffer contraceptive failure
while taking anticonvulsants such as phenobarbitone, phenytoin and carbamazepine. We …

Objective OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is
mainly located in the brain but is also located in liver and several other organs. These …

Objectives The aim of this study was to investigate the frequency of CYP2B6 polymorphisms
(according to ethnicity) and the influence of heterozygosity and homozygosity on plasma …