User profiles for D. J. Canney
DANIEL J. CANNEYTemple University Verified email at temple.edu Cited by 739 |
Pharmacology and Therapeutic Potential of the 5-HT7 Receptor
KM Blattner, DJ Canney, DA Pippin… - ACS Chemical …, 2018 - ACS Publications
It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a
series of 5-HT receptors. The most recently identified member of this family, 5-HT 7 , was first …
series of 5-HT receptors. The most recently identified member of this family, 5-HT 7 , was first …
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA
Privileged structure-based libraries have been shown to provide high affinity lead compounds
for a variety of important biological targets. The present study describes the synthesis and …
for a variety of important biological targets. The present study describes the synthesis and …
Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents
Anticonvulsant properties of compounds that enhance GABA‐mediated inhibition through
modulatory sites on the GABA A receptor [phenobarbital (PB), clonazepam (CZP), α‐ethyl‐α‐…
modulatory sites on the GABA A receptor [phenobarbital (PB), clonazepam (CZP), α‐ethyl‐α‐…
[HTML][HTML] Selectivity profile comparison for certain γ-butyrolactone and oxazolidinone-based ligands on a sigma 2 receptor over sigma 1: a molecular docking approach
Sigma receptors (σ1 R and σ2 R) are pharmacologically characterized membrane-bound
receptors that bind a wide range of chemical compounds. Alzheimer's disease, traumatic brain …
receptors that bind a wide range of chemical compounds. Alzheimer's disease, traumatic brain …
Synthesis and structure-activity studies of alkyl-substituted. gamma.-butyrolactones and. gamma.-thiobutyrolactones: ligands for the picrotoxin receptor
DJ Canney, KD Holland, JA Levine… - Journal of medicinal …, 1991 - ACS Publications
A series of-butyrolactones and 7-thiobutyrolactones possessing a variety of alkyl groups and
alkyl-substitution patterns was prepared and evaluated for anticonvulsant and convulsant …
alkyl-substitution patterns was prepared and evaluated for anticonvulsant and convulsant …
Structure-activity studies of fluoroaljyl-substituted γ-butyrolactone and γ-thiobutyrolactone modulators of GABAA receptor function
DJ Canney, HF Lu, AC McKeon, KW Yoon, K Xu… - Bioorganic & medicinal …, 1998 - Elsevier
Dihydro-2(3H)-furanones (γ-butyrolactones) and dihydro-2(3H)-thiophenones (γ-thiobutyrolactones)
containing fluoroalkyl groups at positions C-3, C-4, and C-5 of the heterocyclic rings …
containing fluoroalkyl groups at positions C-3, C-4, and C-5 of the heterocyclic rings …
In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide
… Canney, Cheryl L. Zimmerman and Swati Nagar … Canney. Other reagents were purchased
from standard sources. All reagents for analytical procedures were of analytical grade. …
from standard sources. All reagents for analytical procedures were of analytical grade. …
Analytical method development for synthesized conjugated metabolites of trans-resveratrol, and application to pharmacokinetic studies
Trans-3,5,4′-trihydroxystilbene (trans-resveratrol, RES) exhibits very low bioavailability
due to extensive conjugative metabolism. Whether RES metabolites exhibit pharmacologic …
due to extensive conjugative metabolism. Whether RES metabolites exhibit pharmacologic …
Synthesis and evaluation of novel, selective, functionalized γ-butyrolactones as sigma-2 ligands
…, JC Gordon, DA Pippin, DJ Canney - Medicinal Chemistry …, 2022 - Springer
… Blass and Canney both have equity interests in Praeventix LLC, which have been reviewed
and approved by Temple University in accordance with its conflict of interest policies. …
and approved by Temple University in accordance with its conflict of interest policies. …
Design, synthesis, and evaluation of novel, selective γ-butyrolactones sigma-2 ligands
…, JC Gordon, DA Pippin, DJ Canney - Medicinal Chemistry …, 2021 - Springer
Nearly 40 years after the first disclosure of sigma receptors, the sigma-2 (σ2) receptor was
recently identified as the Transmembrane Protein 97 (TMEM97, also known as MAC30 (…
recently identified as the Transmembrane Protein 97 (TMEM97, also known as MAC30 (…