Type 2 diabetes mellitus is a severe disease with large economic consequences, which is
significantly under-diagnosed and incompletely treated in the general population. Control of …

An inhibitor of human liver glycogen phosphorylase a (HLGPa) has been identified and
characterized in vitro and in vivo. This substance, [R-(R*,S*)]-5-chloro-N-[3-(dimethylamino)-2-…

Fresh phytoplankton detritus (or phytodetritus) has been reported from numerous deep
seafloor sites in the temperate North Atlantic and Pacific Oceans following seasonal …

The equatorial Pacific forms a band of high, globally significant primary production. This
productivity drops off steeply with distance from equatorial upwelling, yielding large latitudinal …

265 III. Characteristics of CSA-Induced Nonequivalence. 267 A. Origins and Intrinsic
Features. 267 B. Solvent, Temperature, and Concentration Effects. C. Effect of CSA …

Projected sea-level rise will raise coastal water tables, resulting in groundwater hazards that
threaten shallow infrastructure and coastal ecosystem resilience. Here we model a range of …

Background: Glycogen phosphorylases catalyze the breakdown of glycogen to glucose-1-phosphate
for glycolysis. Maintaining control of blood glucose levels is critical in minimizing …

Study region The study region spans coastal California, USA, and focuses on three primary
sites: Arcata, Stinson Beach, and Malibu Lagoon. Study focus 1 m and 2 m sea-level rise (…

Oxygen minimum zones are expected to alter substantially the nature, rates and depths of
bioturbation along continental margins, yet these effects remain poorly studied. Using excess …

We report the X‐ray analysis at 2.0 Å resolution for crystals of the aspartic proteinase
endothiapepsin (EC 3.4.23.6) complexed with a potent difluorostatone‐containing tripeptide renin …