The absorption of methotrexate following intramuscular injection and oral administration of
small doses (>30mg/m 2 ) is rapid and complete, whereas with oral doses in excess of 80mg/…

Several drugs, including clofibrate (ethyl-a-p-chlorophenoxyisobutyrate) 1 , are now available
for the treatment of hyperlipidaemias 2,3 and others are in the process of preclinical or …

Chlorophenoxyisobutyrate (CPIB) and salicylic acid, the metabolites of clofibrate and aspirin,
were quantitated by gas chromatography-mass spectrometry in the effluent of a sewage …

Background This investigation extended the pharmacokinetic analysis of our previous study,
of intravenous dexmedetomidine in 10 healthy male volunteers, and prospectively tested …

The clinical complications of corticosteroid therapy are as protean as the many therapeutic
indications for which their use has been suggested. For a comprehensive review and …

Amphetamine was administered to healthy subjects as the racemic mixture and as (+)‐and (−)‐isomers
under conditions of urine acidification and alkalinization. Plasma and saliva …

The pharmacokinetics of a single 300‐mg oral and intravenous and 14 daily 300‐mg oral
doses of phenytoin were studied in 6 healthy volunteers. The mean plasma elimination t ½ …

The sedative and antihistamine effects of diphenhydramine were assessed in relation to
plasma concentration after placebo, diphenhydramine 50 mg intravenously, and …

… Patients with various types of inoperable carcinomas served as subjects for this study and,
with the exception of VG, all had normal renal function (creatinine less than 1.5 mg/ dl) and …

Long-term effects of Wy-14,643 ([4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid), a
potent hepatic peroxisome proliferator structurally unrelated to the clinically used drug …