The enantioselective glucuronidation of several racemic 2-arylproprionic acids (naproxen,
ibuprofen, and benoxaprofen) was investigated in vitro with immobilized microsomal protein …

Chemical reactionof 1, 4-benzoquinone with GSH gives rise to several multisubstituted
hydroquinone (HQ)-GSH conjugates, each of which causes renal proximal tubular necrosis when …

Biliary Epithelial Cell Proliferation Following α-Naphthylisothiocyanate (ANIT) Treatment:
Relationship to Bile Duct Obstruction. Kossor, DC, Goldstein, RS, Ngo, W., DeNicola, D, B., …

Menadione (2-methyl-1,4-naphthoquinone) was used as a model compound to test the
hypothesis that thioether conjugates of quinones can be toxic to tissues associated with their …

Chlorambucil (p‐(di‐2‐chloroethyl)amino‐γ‐phenylbutyric acid) is a bifunctional alkylating
agent which exhibits acquired drug resistance upon repeated dosing in humans. This …

The overall characteristics of the composites cured with a number of newly synthesized, tertiary
aromatic amines compare favorably to those of resins polymerized with commonly used …

One of the conjugates of melphalan, characterized following incubation with glutathione (GSH)
and immobilized microsomal glutathione-S-transferases, has been identified as 4-(…

Glutathione transferase activity was shown to be present in an immobilized preparation of
microsomal protein. Chlorodinitrobenzene, ethacrynic acid, captopril, styrene oxide, and …

The immobilization of drug‐metabolizing enzymes onto polymeric supports offers several
advantages over use of conventional microsomal or soluble enzyme preparations. These …

The presence in tumor cells and in normal cells of enzymes which metabolize and inactive
alkylating agents appears to play a major role in determining the effectiveness of alkylating …