Effect of obesity on the pharmacokinetics of drugs in humans
MJ Hanley, DR Abernethy, DJ Greenblatt - Clinical pharmacokinetics, 2010 - Springer
The prevalence of obesity has dramatically increased in recent years and now includes a
significant proportion of the world’s children, adolescents and adults. Obesity is linked to a …
significant proportion of the world’s children, adolescents and adults. Obesity is linked to a …
Calcium-antagonist drugs
DR Abernethy, JB Schwartz - New England journal of medicine, 1999 - Mass Medical Soc
Drugs classified as calcium antagonists or calcium-channel blockers were introduced into
clinical medicine in the 1960s and are now among the most frequently prescribed drugs for …
clinical medicine in the 1960s and are now among the most frequently prescribed drugs for …
Pharmacokinetics and clinical effectiveness of methylphenidate
HC Kimko, JT Cross, DR Abernethy - Clinical pharmacokinetics, 1999 - Springer
Methylphenidate is prescribed for over 90% of children in the US diagnosed as having
attention-deficit hyperactivity disorder (ADHD). Although ADHD has been widely studied, the use …
attention-deficit hyperactivity disorder (ADHD). Although ADHD has been widely studied, the use …
A drug burden index to define the functional burden of medications in older people
… Because a general DR 50 of anticholinergic or sedative effect is not identifiable and the need
for normalizing doses remains, we redefined DR 50 to represent a recommended minimum …
for normalizing doses remains, we redefined DR 50 to represent a recommended minimum …
Effect of age, gender, and obesity on midazolam kinetics.
DJ Greenblatt, DR Abernethy, A Locniskar… - …, 1984 - europepmc.org
The effects of age, sex, and obesity on the kinetics of single intravenous (iv) and oral doses
of midazolam were evaluated in healthy volunteers who received 2.5-5 mg of iv midazolam …
of midazolam were evaluated in healthy volunteers who received 2.5-5 mg of iv midazolam …
Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats
…, A Cheng, P Wareski, DR Abernethy… - The FASEB …, 2006 - Wiley Online Library
… intake, another form of DR termed intermittent fasting (IF; … Both forms of DR have been
shown to improve functional and … improved by DR (8), we hypothesize that DR alters cardiac …
shown to improve functional and … improved by DR (8), we hypothesize that DR alters cardiac …
Current status of benzodiazepines
…, RI Shader, DR Abernethy - New England Journal of …, 1983 - Mass Medical Soc
Clinical Use of Benzodiazepines Anxiety Since 1977, several new benzodiazepines have
been marketed in the United States for the treatment of anxiety syndromes 67 68 69 70 71 (…
been marketed in the United States for the treatment of anxiety syndromes 67 68 69 70 71 (…
[HTML][HTML] Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction
E Nagababu, S Ramasamy, DR Abernethy… - Journal of Biological …, 2003 - ASBMB
Recent studies have generated a great deal of interest in a possible role for red blood cells
in the transport of nitric oxide (NO) to the microcirculation and the vascular effect of this nitric …
in the transport of nitric oxide (NO) to the microcirculation and the vascular effect of this nitric …
High‐risk prescribing and incidence of frailty among older community‐dwelling men
…, AJ McLachlan, DR Abernethy… - Clinical …, 2012 - Wiley Online Library
Evidence about the association between treatment with high–risk medicines and frailty in older
individuals is limited. We investigated the relationship between high–risk prescribing and …
individuals is limited. We investigated the relationship between high–risk prescribing and …
[PDF][PDF] Quantitative and systems pharmacology in the post-genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms
…, SRB Allerheiligen, DR Abernethy… - An NIH white …, 2011 - customsitesmedia.usc.edu
Background: This white paper arises from two workshops held at the NIH in 2008 and late
2010 with participation from academia, industry and government (http://meetings. nigms. nih. …
2010 with participation from academia, industry and government (http://meetings. nigms. nih. …