We propose a model of drug pharmacodynamic response that when integrated with a
pharmacokinetic model allows characterization of the temporal aspects of pharmacodynamics as …

Background Remifentanil (GI87084B) is a new short-acting opioid with a unique ester structure.
Metabolism of remifentanil by ester hydrolysis results in very rapid elimination. The aim …

The effect of increasing age on the dose of fentanyl or alfentanil required to produce the
same electroencephalographic(EEG) stage was studied in adult male patients. The …

Fentanyl and alfentanil produce very similar electroencephalographic (EEG) changes in
humans. With increasing serum concentrations of either narcotic, progressive slowing in …

The clinical and electroencephalographic (EEG) effects of the individual ketamine isomers
were compared with the racemic mixture in five volunteers who received each drug on a …

In this chapter, drawn largely from the synthesis of material that we first presented in the sixth
edition of Miller’s Anesthesia, Chap 31 (Stanski and Shafer 2005; used by permission of …

Fentanyl was administered intravenously and transdermally to eight surgical patients to
determine the systemic bioavailability and rate of absorption of the transdermally administered …

The authors compared the pharmacodynamics of sufentanil with those of fentanyl using the
electroencephalogram (EEG) as a measure of opioid drug effect. Sixteen patients were given …

Oral transmucosal fentanyl citrate (OTFC) is a novel, noninvasive dosage form of fentanyl
used to provide children and adults with sedation, anxiolysis, and analgesia. In order to …

… Scott JC, Stanski DR. Decreased fentanyl and alfentanil dose requirements with age: a
simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther 1987;…