Asymmetric induction in an enammonium-iminium rearrangement. Mechanistic insight via NMR, deuterium labeling, and reaction rate studies. Application to the …

…, DF McComsey, DW Graden… - Journal of the …, 1990 - ACS Publications
Reductive deoxygenation of 5a, 5b, 7a, or 7b with borane-THF in trifluoroacetic acid yielded
a product mixture (6a/6b or 4a/4b) highly biased (90-95%) in favor of the trans diastereomer (…

Isolation and characterization of the first host recognition substance for parasitic angiosperms

…, JC Steffens, VS Kamut, DW Graden… - Journal of the …, 1981 - ACS Publications
(100 MHz, acetone-i/6) 5 supported the presence of two separated aromatic chromophores.
Double-resonance experiments clarified an A2B2 pattern and a separate three-…

Synthesis of 5,6‐dimethoxyquinazolin‐2(1H)‐ones

…, JR Roberts, ML Cotter, DW Graden… - Journal of …, 1986 - Wiley Online Library
Synthesis of 5,6‐dimethoxyquinazolin‐2(1H)‐one derivatives was the subject of investigations
leading to the preparation of title compounds 11, 13, 14 and 26. Target quinazolines 1 …

NMR rate study on the Wittig reaction of 2, 2-dimethylpropanal and tributylbutylidenephosphorane

BE Maryanoff, AB Reitz, DW Graden, HR Almond Jr - Tetrahedron letters, 1989 - Elsevier
The fate of intermediate oxaphosphetanes in the reaction of t-BuCHO and Bu 3 PCHPr was
monitored with time. Cis oxaphosphetane 1a was converted to trans oxaphosphetane 1b at …

Conformational study of N-substituted adenines by dynamic proton NMR: Relatively high barrier to rotation about C6-N6 in N3, N6-disubstituted adenines

AB Reitz, DW Graden, AD Jordan Jr… - The Journal of Organic …, 1990 - ACS Publications
Variable-temperature* H NMR experiments on six NŽ-alkyladenines, additionally
substituted at N3, N7, or N9 10, were conducted in DMSO-d6, CDC13, and D20. Two distinct …

2D exchange spectroscopy and the assignment of conformation in macrocyclic ring natural products: cytochalasin B

DW Graden, DG Lynn - Journal of the American Chemical Society, 1984 - ACS Publications
(10) The structures of Cd complexes have been reviewed recently by: Aylett, BJ In “The
Chemistry Biochemistry and Biology of Cadmium”; Webb, M., Ed.; Elsevier/North Holland: …

The application of two-dimensional nmr cross relaxation spectroscopy to natural product structure determination: talaromycin B

WC Hutton, NJ Phillips, DW Graden… - Journal of the Chemical …, 1983 - pubs.rsc.org
Two-dimensional, cross relaxation, correlated nmr spectroscopy is a powerful method for
elucidating intermolecular, dipolar interactions of molecules in the extreme narrowing …

1H and 13C NMR spectra of pseudomorphine and dimethylpseudomorphine

DW Graden, GW Caldwell, FJ Villani… - Magnetic resonance …, 1990 - Wiley Online Library
The 1 H and 13 C NMR spectra of 7,7′,8,8′‐tetradehydro‐4,5:4′,5′‐diepoxy‐17,17′‐dimethyl‐[2,2′‐bimorphinan]‐3,3′,6,6′‐tetrol;
[2,2′‐bimorphine] (pseudomorphine) and …

The metabolism of etintidine in rat, dog, and human.

FA Wong, JR Lloyd, DW Graden - Drug metabolism and disposition, 1990 - ASPET
The metabolic fate of etintidine, a new H2-receptor antagonist, was studied in the rat, dog,
and human. Following oral or iv administration of [14C]etintidine HCl to rats, 63-72% of the …

Differentiation between N (im)-substituted histidines by NOE difference spectroscopy

DW Graden, ML Cotter, SD Levine - The Journal of Organic …, 1985 - ACS Publications
Discussion In the case of IV-BOC-IV (im)-benzyl-D-histidine (3), the signal intensity of the
benzyl methylene protons was en-hanced when both imidazole protons H-2 and H-4 were …