… Hein DW N-Acetyltransferase genetics and their role in predisposition to aromatic and …
Fretland AJ, Leff MA, Doll MA, Hein DW Functional analysis of single nucleotide substitutions in …

Aromatic and heterocyclic amines require metabolic activation to electrophilic intermediates
that initiate carcinogenesis. N-Acetyltransferase 1 (NAT1) and 2 (NAT2) are important …

A consolidated classification system is described for prokaryotic and eukaryotic N-acetyltransferases
in accordance with the international rules for gene nomenclature. The root symbol (…

Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC)
database containing information on over 15,000 control (noncancer) subjects, the allele …

The formation of2-aryl-and 2-alkyl-substituted benzimidazoles, benzoxazoles and benzothiazoles
by the polyphosphoric acid-catalyzed condensation of a carboxylic acid, ester, amide …

Background Many reported associations between common genetic polymorphisms and
complex diseases have not been confirmed in subsequent studies. An exception could be the …

A genetic polymorphism at the NAT2 gene locus, encoding for polymorphic N-acetyltransferase
(NAT2), segregates individuals into rapid, intermediate or slow acetylator phenotypes. …

The ideal suture is strong, handles easily, and forms secure knots. It causes minimal tissue
inflammation and does not promote infection. It stretches and accommodates wound edema. …

… than from a slow acetylator, while the sulfamethazine NAT activity was 4-fold higher and
the PABA NAT activity was essentially equivalent• These findings were later extended by Hein …

Background & Aims : Oxidative stress contributes to early alcohol-induced liver injury, and
superoxide (O 2 ·− ) production from NADPH oxidase plays a key role. However, the …